Treatment of Nonclassic 11-Hydroxylase Deficiency with Hair, Skin, and Nails, an Over-the-Counter, Insulin Sensitizing Vitamin/Mineral Supplement

In 2019, a study was conducted on a 62-year-old Afro-Caribbean female with non-classic 11-hydroxylase deficiency, who was experiencing hair loss and had a risk of developing Type 2 Diabetes Mellitus (T2DM). After intolerance to metformin, she was given a daily supplement for 114 days containing beta carotene 2500 IU, vitamin C 100mg, biotin 2500 mcg, zinc oxide 11mg, and copper oxide 0.9mg. Following this treatment, her serum 11-deoxycortisol levels fell from 80ng/dl to < 20 ng/dl, and her Hemoglobin A1c levels decreased from 5.7% to 5.3%, indicating an improvement in her condition. The study concluded that the supplement, which contains elements reported to have insulin sensitizing properties, may be an effective treatment for non-classic 11-hydroxylase deficiency and could potentially be used in treating other insulin resistance conditions if the results are confirmed in larger studies.