Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root

    January 2017 in “ Case reports in endocrinology
    Daniel Powell, Taiga Inoue, Gül Bahtiyar, Gabriel Fenteany, Alan Sacerdote
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    Studysummary This report describes an elderly woman whose nonclassic 11-hydroxylase deficiency, presenting as acne and male pattern alopecia, may have been ameliorated by Ashwagandha root in a dose-related manner. Our plain-language summary of this paper — not a Tressless recommendation.
    The document discussed the treatment of nonclassic 11-hydroxylase deficiency using Ashwagandha root, highlighting a case of a 78-year-old woman who showed significant improvement in symptoms such as acne and alopecia over three years. The treatment normalized her serum 11-deoxycortisol levels and improved her hair loss and acne, suggesting a dose-related effect of Ashwagandha. The study proposed Ashwagandha as a potential alternative treatment for nonclassic 11-hydroxylase deficiency, offering a natural option with fewer side effects, and emphasized the need for further research to confirm these findings. The treatment was well-tolerated without significant changes in vital signs or laboratory parameters.
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