Roux-En-Y Gastric Bypass in the Treatment of Non-Classic Congenital Adrenal Hyperplasia Due to 11-Hydroxylase Deficiency

The document discussed the use of Roux-en-Y gastric bypass (RYGB) as a treatment for non-classic congenital adrenal hyperplasia (NCAH) due to 11-hydroxylase deficiency, focusing on a case report of a 39-year-old obese woman. Post-surgery, the patient experienced significant clinical improvements, including a reduction in androgen levels, normalization of serum 11-deoxycortisol without medication, and resolution of symptoms such as alopecia, hirsutism, and irregular menses. The findings suggested that RYGB could be a viable therapeutic option for managing NCAH associated with obesity and metabolic syndrome, though the report called for larger, randomized trials to confirm these results.