TLDR Glucocorticoid and mineralocorticoid therapy effectively manage Congenital Adrenal Hyperplasia symptoms but have limitations.
The chapter discussed the management of Congenital Adrenal Hyperplasia (CAH) in adolescents and adults, focusing on glucocorticoid and mineralocorticoid replacement therapy as the gold standard treatment. This approach aimed to address enzyme mutations affecting adrenal steroidogenesis, which led to overactivity of the hypothalamic-pituitary-adrenal axis and renin-angiotensin aldosterone system. The therapy was effective in managing symptoms such as amenorrhea, hirsutism, and alopecia, and in preventing complications like premature epiphyseal closure. However, limitations existed, particularly in non-classical CAH, where balancing androgen production and glucocorticoid dosing was challenging. The chapter also highlighted the importance of adjusting glucocorticoid doses during stress and the potential future directions for CAH treatment, including addressing insulin resistance.
105 citations,
February 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.
35 citations,
January 2011 in “Clinical Endocrinology” Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.
88 citations,
April 2017 in “Journal of Pediatric and Adolescent Gynecology” The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.
29 citations,
December 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.
16 citations,
September 2008 in “Dermatologic Therapy” CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.
August 2022 in “IntechOpen eBooks” Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.
July 2017 in “Contemporary Endocrinology” The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.
