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The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

Ginseng is possibly safe but its effectiveness is unclear due to poor quality studies and mixed results.