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This article reviews central centrifugal cicatricial alopecia, particularly in women of African descent, and explains its progression and symptoms but provides no new clinical findings.

This study suggests that central centrifugal cicatricial alopecia may involve a CD4-predominant T-cell process with potential PD1/PDL1 pathway involvement, indicated by increased caspase 3 expression and loss of PDL1.

This review examines the various potential causes of bitemporal hair loss, emphasizing the importance of prompt diagnosis to prevent further hair loss in scarring conditions; it reports no new clinical results.

Hair shaft changes may be linked to CCCA, but their role is unclear.

This article reports three cases of African American men with central centrifugal cicatricial alopecia, highlighting the need to consider this diagnosis for male patients with vertex hair loss and scalp symptoms.

This review discusses central centrifugal cicatricial alopecia, emphasizing its clinical features, potential contributing factors, and treatment options, but does not report new clinical findings.

This case study describes successful hair growth in a 59-year-old African-American female with central centrifugal cicatricial alopecia after switching to oral minoxidil treatment.

This study observed that sebaceous glands were preserved in some patients with central centrifugal cicatricial alopecia, suggesting early gland loss may not be a key feature of the condition.

This study identified CCCA in 10 children of African descent, highlighting the occurrence of this scarring alopecia in patients under 18 and the importance of early diagnosis for better outcomes.

This study found that patients with central centrifugal cicatricial alopecia were less likely to report treatment improvement and more commonly associated with certain hairstyling practices compared to those with other scarring alopecias.

This review discusses central centrifugal cicatricial alopecia in adult women of African descent and reports no clinical results; the authors highlight traditional treatments and their impact on quality of life.

This study found that patients with central centrifugal cicatricial alopecia preferred shared decision-making with their doctors regarding treatment management.

Genetic changes in specific proteins contribute to hair loss in some women of African descent.

This study highlighted that diagnostic complexities can lead to misdiagnosis of alopecia areata in Black patients, commonly due to similar presentations of scarring alopecias and multiple hair loss types co-occurring within a single patient.

This study observed that Black women with central centrifugal cicatricial alopecia had a higher prevalence of uterine leiomyomas compared to those with lichen planopilaris, suggesting a potential association between the conditions.

Diagnosing and treating CCCA requires understanding multiple causes and using various diagnostic tools.

This study highlights a lack of research on the use of topical and low-dose oral minoxidil for treating scarring alopecia, despite their widespread application in other hair loss conditions.

This study reviewed existing literature and found that androgenic alopecia may be associated with cardiovascular risk factors, while evidence for alopecia areata and cicatricial alopecias is limited and sometimes contradictory.

In this study, a case of a 70-year-old woman with central centrifugal cicatricial alopecia showed that using a high-quality hair prosthesis improved her quality of life and mood, as measured by PHQ-9 and Skindex-29 scores, though such wigs are rarely covered by insurance.

More research is needed on CCCA in children, especially Black and Asian adolescents.

The authors maintain there is a significant link between vitamin D deficiency and central centrifugal cicatricial alopecia in Black patients, and call for more research on the topic.

This article explores potential risk factors for central centrifugal cicatricial alopecia and suggests that seborrheic dermatitis may play a role in its development, but it reports no new scientific findings.

In this study, researchers observed that approximately 25% of patients experienced hair loss after COVID-19 infection, with nonscarring alopecia being the most common form.

This article discusses features, genetics, and diagnostic challenges of central centrifugal cicatricial alopecia in African American women but reports no new clinical results.

This study found that fibrosis-associated trochanters in central centrifugal cicatricial alopecia are enriched with hair follicle stem cells and may indicate a disrupted stem cell niche contributing to scarring.

Hair shaft malformation contributes to Central Centrifugal Cicatricial Alopecia.

This study found that mutations in the PADI3 gene, which is important for hair shaft formation, may contribute to central centrifugal cicatricial alopecia among patients.

CCCA in women of African ancestry may be caused by PADI3 gene mutations and intense hair grooming.

Elderly patients with CCCA were all African American with low vitamin D, but no iron or zinc deficiencies, and no hormonal imbalances compared to younger patients.

A woman's hair loss was correctly diagnosed as Lichen planopilaris after initial misdiagnosis, highlighting the usefulness of trichoscopy in diagnosing hair disorders.