142 citations
,
February 2016 in “Science” This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.
142 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This workshop overview concluded that follicular epithelial stem cells are multipotent and located in the bulge region of hair follicles, contributing to hair, epidermis, and sebaceous gland formation.
141 citations
,
August 2017 in “Developmental Dynamics” This review discusses the cellular and molecular changes involved in cutaneous wound re-epithelialization and EMT, highlighting their similarities and differences, but reports no new clinical results.
141 citations
,
September 2016 in “European Journal of Dermatology” This review examines dermatological side effects of taxane chemotherapy reported in past studies and highlights the necessity for identifying and managing these conditions to maintain cancer patients' quality of life; it presents no new clinical results.
141 citations
,
May 2007 in “Cancer Research” This study found that CD34 is necessary for TPA-induced activation of hair follicle stem cells and tumor formation in mice, with CD34 knockout mice showing delayed and reduced tumor development compared to wild-types.
141 citations
,
January 1984 in “Journal of The American Academy of Dermatology” This review discusses skin changes during pregnancy, highlighting both pregnancy-specific and common physiologic changes, but reports no new clinical findings.
141 citations
,
February 1988 in “Molecular and Cellular Biology” This study found that despite strong homology between two K16 genes, only one encoded a functional protein that assembled into keratin filaments in epithelial cells, possibly due to promoter strength differences.
140 citations
,
February 2014 in “Neuron” This study found that the opioid system, particularly via the delta opioid receptor, broadly regulates cutaneous mechanosensation, including touch, and suggests targeting this receptor could alleviate injury-induced mechanical hypersensitivity.
140 citations
,
January 2021 in “Journal of the International Society of Sports Nutrition” This source reports that while creatine supplementation is popular for improving muscle mass and performance, questions about its efficacy and safety persist. An expert team is reviewing literature to address concerns like water retention, renal effects, and its benefits across different populations and uses.
140 citations
,
March 2013 in “The journal of immunology/The Journal of immunology” This study found that IL-7 is crucial for the survival of memory regulatory T cells in the skin of mice, whereas IL-2 is essential for their initial generation but not for their maintenance.
140 citations
,
December 1998 in “Journal of Investigative Dermatology” Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.
140 citations
,
August 2010 in “Pigment Cell & Melanoma Research” This article discusses mouse genetic studies to explore factors influencing melanogenesis, highlighting pH and cysteine's roles, and proposes a hypothesis for human hair color diversity; it reports no new results.
139 citations
,
December 2020 in “Cell Stem Cell” Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
139 citations
,
May 2020 in “Stem Cell Research & Therapy” In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.
139 citations
,
August 2018 in “Development” This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.
139 citations
,
October 1999 in “Environmental Health Perspectives” This article reviews the scientific exploration of Ayurvedic medicinal plants and discusses their modern applications, such as a drug developed from Commiphora wightti for lipid disorders, without reporting new clinical findings.
139 citations
,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a new type II cytokeratin, named K6hf, exclusively expressed in the companion layer of the human hair follicle, distinguishing it from other keratins and suggesting a unique biochemical role.
139 citations
,
July 1991 in “Journal of The American Academy of Dermatology” This article discusses the structure of hair follicles and their significance in evaluating hair disorders, but it does not report any new research findings.
139 citations
,
August 2006 in “Molecular and Cellular Biology” This study found that Rac1 is crucial for maintaining the integrity of hair follicle structure but is not needed for skin epidermis maintenance in mice.
138 citations
,
April 2003 in “Carcinogenesis” This study found that 2-methoxyestradiol induces apoptosis in human prostate cancer cells by activating p53 through a pathway dependent on p38/JNK-mediated NFkappaB/AP-1 activation, with JNK-dependent Bcl-2 phosphorylation also playing a critical role.
138 citations
,
March 2021 in “Journal of the American Academy of Dermatology” This study found that treatment with ritlecitinib or brepocitinib was effective in improving scalp hair loss for patients with alopecia areata over 24 weeks compared to placebo.
138 citations
,
July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.
138 citations
,
February 2007 in “European journal of cancer” This review discusses the classification, pathogenesis, and management of skin, hair, nail, and mucosal changes due to EGFR inhibitors, emphasizing the importance of informing patients to improve therapy compliance.
138 citations
,
March 2001 in “Clinics in Dermatology” This review discusses the relationship between perceived stress and hair loss or graying, exploring hair follicles as a model system but reports no new clinical results.
138 citations
,
November 1977 in “Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics” 137 citations
,
January 2006 in “Frontiers in bioscience” This review discusses the role of corticotropin-releasing hormone in human skin, focusing on its regulation, receptors, and functions, and highlights parallels with the hypothalamo-pituitary-adrenal axis; it reports no new research findings.
137 citations
,
May 1984 in “Journal of Investigative Dermatology” Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.
137 citations
,
July 2004 in “Journal of The American Academy of Dermatology” This study observed that triple horizontal scalp biopsies provided a more accurate diagnosis of female pattern hair loss in women than a single horizontal biopsy, especially for those with advanced hair loss.
136 citations
,
May 2019 in “Cells” This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.
136 citations
,
February 2017 in “International Journal of Molecular Sciences” This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.