69 citations
,
December 2011 in “Journal of Ethnopharmacology” This study found that Carthamus tinctorius exhibited the strongest 5α-reductase inhibitory and hair growth promoting activities among evaluated Thai herbs, suggesting potential for developing alternative hair loss treatments.
69 citations
,
September 2006 in “Human Reproduction” This study found that CD45RO+ cells, a subtype of T lymphocytes, were notably reduced in the ovarian follicles of women with PCOS, which may contribute to the condition's pathogenesis.
69 citations
,
December 2005 in “Nature Clinical Practice Endocrinology & Metabolism” Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.
68 citations
,
August 2014 in “Stem Cells Translational Medicine” This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
68 citations
,
September 2003 in “British Journal of Dermatology” This study found that in thin cutaneous melanomas, tumor regression is associated with a higher risk of sentinel lymph node involvement.
67 citations
,
March 1987 in “Journal of The American Academy of Dermatology” This study found that both 2% and 3% minoxidil resulted in a significant increase in hair counts for participants with androgenetic alopecia over 12 months.
65 citations
,
March 2018 in “Journal of Dermatological Science” This review discusses the role of mechanical forces in skin homeostasis and disease development, including their impact on conditions like keloids, androgenetic alopecia, and acral melanoma, and reports no clinical results; the authors propose modifying these forces as a potential therapeutic strategy.
65 citations
,
September 2017 in “British Journal of Cancer” In this large British study, prostate cancer risk was linked to ethnicity, family history, prostate enlargement, and PSA testing, while excess adiposity, smoking, diabetes, and certain lifestyle factors were associated with a reduced risk.
65 citations
,
September 2010 in “Journal of the Neurological Sciences” This article discusses Kennedy's disease, detailing its genetic cause, symptoms, and diagnostic criteria, but reports no new clinical findings and highlights a lack of causal therapy.
64 citations
,
August 2013 in “Mayo Clinic Proceedings” This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.
64 citations
,
March 2006 in “Food Chemistry” In castrated rats, this study found that triterpenoids from Ganoderma lucidum inhibited both types of 5α-reductase and reduced prostate growth linked to testosterone but not dihydrotestosterone.
63 citations
,
January 2012 in “The European Journal of Contraception & Reproductive Health Care” This study concluded that combined hormonal contraceptives containing desogestrel, drospirenone, or cyproterone acetate were associated with a higher risk of venous thromboembolism compared to those containing levonorgestrel.
63 citations
,
March 1995 in “International Journal of Dermatology” Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.
61 citations
,
October 2010 in “Postgraduate Medical Journal” This study found that dermatological issues, such as xerosis and pigmentation, are common in chronic kidney disease patients and increase with the severity and duration of the disease, indicating that dialysis often exacerbates these conditions.
60 citations
,
November 2020 in “International Journal of Medical Sciences” This review highlights the potential of near-infrared light therapy to improve metabolic, antioxidant, and cognitive functions without adverse effects, and supports its use for visual and neurological conditions through molecular and cellular mechanisms, as reported in this source.
59 citations
,
November 2018 in “Psychoneuroendocrinology” This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.
58 citations
,
March 2013 in “Human Reproduction Update” This review discusses various substances that can impact male fertility and stresses that products should be confirmed 'sperm-safe' through rigorous testing, not assumptions; it reports no new study results.
58 citations
,
June 2006 in “Plastic and Reconstructive Surgery” This study successfully developed a reproducible mouse model demonstrating fetal scarless wound healing, which may provide insights for minimizing scarring in adults.
55 citations
,
March 2000 in “American journal of clinical dermatology” Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.
54 citations
,
January 2018 in “Scientific reports” This study used proteomics to identify various proteins in human hair, which may help develop novel biomarkers for hair health, disease, and aging.
52 citations
,
February 2012 in “Plastic Surgery International” This review describes techniques for successful skin grafting and variations of the procedure, reporting no new clinical results.
52 citations
,
June 1981 in “International Journal of Dermatology” Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
51 citations
,
March 2019 in “Journal of cellular physiology” This review discusses the use of platelet lysate and its growth factors in treating diseases and regenerative medicine but reports no new clinical findings.
51 citations
,
May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.
48 citations
,
May 2023 in “Nature Communications” In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.
48 citations
,
May 2012 in “Journal of Midwifery & Women's Health” This review discusses the symptoms, diagnosis, and current treatment recommendations for polycystic ovary syndrome, noting that many women may remain undiagnosed and at risk for complications.
47 citations
,
June 2019 in “Nature Communications” This study found that self-noncoding dsRNA activates TLR3 to stimulate intrinsic retinoic acid synthesis, promoting new hair follicle formation in wounded mice and showing similar gene expression changes in humans treated with rejuvenation lasers.
47 citations
,
February 2019 in “Journal of The American Academy of Dermatology” This article reviews the unique health issues and preventive care recommendations for LGBT individuals, emphasizing dermatologic considerations and the importance of culturally competent care, but reports no new clinical findings.
47 citations
,
January 2003 in “American Journal of Clinical Dermatology” This article discusses the potential for severe adverse cutaneous drug reactions with mood-stabilizing agents, emphasizing the importance of monitoring and patient communication, but reports no new clinical findings.
47 citations
,
August 2000 in “Endocrine Reviews” This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.