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      Vitiligo: A Comprehensive Overview

      research Vitiligo: A comprehensive overview

      532 citations , August 2011 in “Journal of the American Academy of Dermatology”
      This article discusses the clinical presentation, histopathologic findings, and pathogenesis hypotheses of vitiligo without reporting new clinical results.
      Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions

      research Melatonin membrane receptors in peripheral tissues: Distribution and functions

      506 citations , January 2012 in “Molecular and Cellular Endocrinology”
      This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.
      Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

      research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

      474 citations , January 2012 in “Chemistry & biology”
      This review discusses the discovery and potential therapeutic uses of proteasome inhibitors across various diseases, including cancer and autoimmune conditions, but does not present new clinical data.
      Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

      research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

      451 citations , March 2005 in “Endocrine Reviews”
      This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.
      The Browning of White Adipose Tissue: Some Burning Issues

      research The Browning of White Adipose Tissue: Some Burning Issues

      437 citations , August 2014 in “Cell metabolism”
      This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.
      Developmental Origin of Polycystic Ovary Syndrome: A Hypothesis

      research Developmental origin of polycystic ovary syndrome - a hypothesis

      430 citations , July 2002 in “Journal of Endocrinology”
      This hypothesis paper suggests that PCOS may result from genetically determined ovarian hypersecretion of androgens, influencing hormone regulation and insulin resistance, with obesity further affecting its severity; no new clinical results are reported.
      Obesity and the Skin: Skin Physiology and Skin Manifestations of Obesity

      research Obesity and the skin: Skin physiology and skin manifestations of obesity

      405 citations , May 2007 in “Journal of The American Academy of Dermatology”
      This review discusses the profound impact of obesity on skin physiology and dermatologic conditions and reports no new experimental results, recommending awareness and treatment strategy development for obesity-associated dermatoses.
      Is Dehydroepiandrosterone a Hormone?

      research Is dehydroepiandrosterone a hormone?

      403 citations , November 2005 in “Journal of Endocrinology”
      This review discusses the role of DHEA in intracrinology, highlighting its impact on breast and prostate cancer treatment and potential as a menopause therapy, but reports no new research findings.
      Skin Melanocytes: Biology and Development

      research Skin melanocytes: biology and development

      401 citations , January 2013 in “Postepy Dermatologii I Alergologii”
      This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.
      The Neurobiology of Sexual Function

      research The Neurobiology of Sexual Function

      393 citations , November 2000 in “Archives of General Psychiatry”
      This review discusses the neurobiology of sexual function and reports no new results; the authors cover multiple endocrine and neurotransmitter influences on sexual desire, arousal, and orgasm stages.
      Neuroimmunology of Stress: Skin Takes Center Stage

      research Neuroimmunology of Stress: Skin Takes Center Stage

      375 citations , July 2006 in “Journal of Investigative Dermatology”
      This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.
      Overweight and Obesity in Children and Adolescents

      research Overweight and Obesity in Children and Adolescents

      356 citations , September 2014 in “Journal of Clinical Research in Pediatric Endocrinology”
      This article discusses the rising prevalence and serious implications of childhood obesity and reports no new experimental findings; the authors emphasize the importance of prevention and early intervention through comprehensive management programs.
      Auxin And Ethylene: Collaborators Or Competitors?

      research Auxin and ethylene: collaborators or competitors?

      356 citations , March 2012 in “Trends in Plant Science”
      This review discusses the crosstalk between auxin and ethylene in seedling growth and development, emphasizing how ethylene modulates auxin's effects across different tissues.
      Treatment of Invasive Aspergillosis with Itraconazole

      research Treatment of invasive aspergillosis with itraconazole

      350 citations , June 1989 in “The American Journal of Medicine”
      This study suggests that itraconazole may significantly improve therapy for aspergillosis, with 12 out of 15 evaluable patients responding to the treatment.
      IL-17-Producing Gamma Delta T Cells Enhance Bone Regeneration

      research IL-17-producing γδ T cells enhance bone regeneration

      343 citations , March 2016 in “Nature Communications”
      This study found that IL-17A-producing γδ T cells play a key role in bone fracture healing by promoting bone formation, with deficiencies leading to impaired repair in mice.
      The Dynamics of the Skin’s Immune System

      research The Dynamics of the Skin’s Immune System

      306 citations , April 2019 in “International Journal of Molecular Sciences”
      This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.
      Sexual Hormones in Human Skin

      research Sexual Hormones in Human Skin

      305 citations , February 2007 in “Hormone and metabolic research”
      This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.
      Fibroblast Heterogeneity: Implications for Human Disease

      research Fibroblast heterogeneity: implications for human disease

      299 citations , January 2018 in “Journal of Clinical Investigation”
      This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.
      The Rotterdam Study: 2014 Objectives and Design Update

      research The Rotterdam Study: 2014 objectives and design update

      266 citations , November 2013 in “European Journal of Epidemiology”
      This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
      Selective Follicular Targeting by Modification of the Particle Sizes

      research Selective follicular targeting by modification of the particle sizes

      263 citations , February 2011 in “Journal of Controlled Release”
      This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.
      Interrelation of Immunity and Tissue Repair or Regeneration

      research Interrelation of immunity and tissue repair or regeneration

      252 citations , April 2009 in “Seminars in Cell & Developmental Biology”
      This review discusses the complex role of the immune system in tissue repair and regeneration, highlighting its positive and negative influences but reports no new clinical findings.
      The Pathophysiology of Polycystic Ovary Syndrome

      research The pathophysiology of polycystic ovary syndrome

      249 citations , November 2003 in “Clinical endocrinology”
      This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.