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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Finasteride safely lowers DHT levels without affecting testosterone.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Finasteride effectively blocks enzyme causing male pattern baldness.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Finasteride may cause long-lasting sexual side effects.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Long-term use of minoxidil for high blood pressure can delay kidney failure in some patients and improve kidney function in others with severe hypertension.

Oral contraceptives provide various health benefits beyond birth control, including managing menstrual issues, skin conditions, pain, and reducing the risk of certain cancers.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

Sabal and Urtica extract works as well as finasteride for treating BPH, with fewer side effects.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

Both drugs lower DHT levels, with GI198745 being more effective.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Edible seeds from the Cucurbitaceae family like pumpkin and watermelon seeds are nutritious and may have health benefits, but eating too much can cause side effects.

Dermatologists are more accurate than general practitioners in diagnosing skin conditions, especially skin cancer.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Certain drugs that block specific enzymes can help treat prostate diseases.

Antiandrogens may help treat conditions like excessive hair growth, prostate tumors, male baldness, and acne by blocking male hormone effects.

Finasteride might lower the risk of low-grade prostate cancer but not high-grade cancer, while alpha-blockers might reduce high-grade cancer risk.