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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Lichen planus is a skin condition that can resolve on its own, is linked to hepatitis C, and increases the risk of skin cancer.

Generalized pustular psoriasis patients often need strong medication and careful treatment due to flare-ups and complications.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Postinflammatory hyperpigmentation causes dark skin patches and needs personalized treatment.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.

Minoxidil boosts hair growth by activating PGHS-1.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Aromatase gene variation may increase female hair loss risk.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

Minoxidil activates hair growth by being sulfated by P-PST in the human liver.

Shampoos are designed to clean and improve hair and scalp health, with specific ingredients for different hair types and conditions.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

We don't fully understand how sunlight damages different types of hair.

Cancer development is like natural selection, involving mutated cells and environmental factors.

Folliculitis is an inflammation of hair follicles that requires proper diagnosis and treatment based on the specific cause.

Photothermal hydrogels are promising for infection control and tissue repair, and combining them with other treatments could improve results and lower costs.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.