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    Glossary Aromatase

    enzyme converting androgens into estrogens

    Aromatase is an enzyme that converts androgens (male hormones) into estrogens (female hormones). This process is crucial for maintaining the balance of sex hormones in both men and women, and it plays a significant role in various biological functions, including reproductive health and bone growth. In the context of hair, aromatase activity can influence hair growth patterns and conditions like alopecia.

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    1. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997 · 416 citations
    2. 17α‐estradiol induces aromatase activity in intact human anagen hair follicles <i>ex vivo</i> Experimental Dermatology · 2002 · 94 citations
    3. Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy Current Oncology · 2007 · 90 citations
    4. Gene-wide association study between the aromatase gene (<i>CYP19A1</i>) and female pattern hair loss British Journal of Dermatology · 2009 · 77 citations
    5. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    6. Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: A possible androgenic bone protective effects induced by exemestane Bone · 2006 · 50 citations
    7. Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin Molecular and Cellular Endocrinology · 2012 · 46 citations
    8. Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 2005 · 44 citations
    9. Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors The Journal of Clinical Endocrinology and Metabolism · 2018 · 37 citations
    10. The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog <i>Silurana tropicalis</i> Sexual Development · 2009 · 37 citations
    11. Aromatase deficiency in a male patient - Case report and review of the literature. Bone · 2016 · 36 citations
    12. Aromatase inhibitor therapy and hair loss among breast cancer survivors Breast Cancer Research and Treatment · 2013 · 34 citations
    13. 5α-Reductase isozymes and aromatase mRNA levels in plucked hair from young women with female pattern hair loss Archives of Dermatological Research · 2017 · 21 citations
    14. Aromatase inhibitors induce ‘male pattern hair loss’ in women? Annals of Oncology · 2013 · 19 citations
    15. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss British Journal of Dermatology · 2011 · 15 citations
    16. Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice Neurochemistry International · 2015 · 14 citations
    17. Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats Pharmacology Biochemistry and Behavior · 2010 · 13 citations
    18. Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice Epilepsy research · 2018 · 11 citations
    19. Art of prevention: The importance of dermatologic care when using aromatase inhibitors International Journal of Women’s Dermatology · 2021 · 10 citations
    20. A Phase II Study of Vaginal Testosterone Cream (TEST) vs. Estring for Vaginal Dryness or Decreased Libido in Women with Early Stage Breast Cancer (BC) Treated with Aromatase Inhibitors (AIs). Cancer Research · 2009 · 9 citations
    21. CDK4/6 plus aromatase inhibitor-induced alopecia in breast cancer patients. Journal of Clinical Oncology · 2019 · 4 citations
    22. Evaluation of dermatologic adverse events associated with aromatase inhibitors: insights from the FAERS database Frontiers in Pharmacology · 2025 · 2 citations
    23. Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network Expert Opinion on Drug Safety · 2024 · 1 citations
    24. Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase And 5-Alpha Reductase Inhibition Pharmacognosy Journal · 2024 · 1 citations
    25. Aromatase inhibitor–induced hair loss in two adolescents Pediatric Dermatology · 2020 · 1 citations
    26. Inibição seletiva da 5α-redutase e preservação da aromatase no transplante capilar Revista Eletrônica Polidisciplinar Voos. · 2026
    27. mRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia International Journal of Molecular Sciences · 2023
    28. 202 Activation of breast cancer cell proliferation by ROR-alpha through aromatase promoter Ejc Supplements · 2010
    29. Expressão gênica da aromatase em folículos pilosos do vértice do escalpo de mulheres com ciclos ovulatórios e pacientes com síndrome dos ovários policísticos (PCOS) : análise de associação com parâmetros hormonais e metabolicos LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · 2008
    30. SAT-288 Successful Virilization of a PAIS Patient with a Missense Mutation In The Ligand-binding Domain Of The Androgen Receptor with Combined High-dose Testosterone and Aromatase Inhibitor Journal of the Endocrine Society · 2019