50 citations
,
September 2012 in “Developmental Biology” This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.
5 citations
,
September 2019 in “The Open biomarkers journal” This study found that linoleic acid may help protect against acrylamide toxicity in female albino rats.
53 citations
,
June 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study observed that abnormal hormone levels were associated with lower disease activity in frontal fibrosing alopecia, while thyroid disorders were a common comorbidity among the affected population.
1 citations
,
October 2008 in “Expert Review of Dermatology” This review discusses frontal fibrosing alopecia, noting its frequent misdiagnosis and highlighting the need for larger studies to better understand its epidemiology, causes, and treatment options; it reports no new clinical findings.
August 2026 in “ACTA MEDICA IRANICA” This study found that women with female pattern hair loss exhibited hormonal imbalances, with the Free Androgen Index being a particularly effective diagnostic marker.
24 citations
,
July 2018 in “British Journal of Dermatology” Contact allergies might contribute to frontal fibrosing alopecia.
61 citations
,
January 2019 in “American Journal of Clinical Dermatology” This review discusses the potential causes and treatments for frontal fibrosing alopecia but reports no new clinical findings, highlighting the need for further research to understand its pathogenesis and develop validated treatments.
April 2023 in “World Journal Of Advanced Research and Reviews” This study in Morocco found that all women with frontal fibrosing alopecia presented frontotemporal hairline recession, with trichoscopic features such as perifollicular erythema and follicular hyperkeratosis being indicative of the condition, and suggested a potential link between cosmetic products or emotional factors and the disease.
23 citations
,
December 2017 in “Scientific Reports” This study found that the ARL15 gene affects adipocyte differentiation and adiponectin secretion, and suggests that ARL15 haploinsufficiency may predispose individuals to lipodystrophy.
19 citations
,
November 1979 in “Archives of dermatology” This case report discusses the potential use of topical tretinoin for treating Fox-Fordyce disease, but provides no new clinical results.
98 citations
,
January 2013 in “Journal of The American Academy of Dermatology” This study reported that while various treatments for frontal fibrosing alopecia showed limited effectiveness, dutasteride most effectively stabilized the condition among patients at Duke University.
1 citations
,
November 1995 in “Postgraduate medical journal” This article presents a case of 5-alpha-reductase deficiency in a Saudi individual, reporting no new research findings.
November 2023 in “Indian Journal of Dermatology” This study from North-East India analyzed 21 cases of frontal fibrosing alopecia, noting a high prevalence in post-menopausal women and distinct histological features such as perifollicular lymphocytic infiltrate and hydropic degeneration.
October 2022 in “Revista Eletrônica Acervo Médico” This narrative review discusses adverse effects associated with 5-ARI treatments for male-pattern baldness and benign prostate hyperplasia, including sexual health, neurological, endocrine, metabolic, and cardiovascular impacts, and emphasizes careful prescription assessment.
21 citations
,
October 2007 in “Journal of Investigative Dermatology” Fetuin-A helps wounds heal without scars by promoting cell movement.
1 citations
,
January 2007 in “Heterocyclic Communications” This study reports a new method for selectively synthesizing finasteride Form-I in good yield using water as an ecofriendly solvent at room temperature.
9 citations
,
March 1991 in “Endocrinology” This study in rats suggests that combining the 5 alpha-reductase inhibitor 4-MA with the antiandrogen Flutamide may enhance prostate cancer therapy by additively inhibiting prostatic growth and mRNA levels of androgen-sensitive prostatic binding proteins.
25 citations
,
April 2008 in “Clinical and experimental dermatology” This case series describes Erythromelanosis follicularis faciei et colli in five Indian patients, suggesting it may be more common than currently reported.
14 citations
,
February 1991 in “FEBS Letters” This study found that introducing rat ornithine transcarbamylase gene into spf-ash mice improved liver and intestinal enzyme activity and normalized some metabolic indicators.
August 2024 in “Latin American Journal of Development” In this review, the authors highlight the involvement of the 5α-reductase enzyme family in androgen-dependent disorders, noting the discovery of a novel isoform, SRD5A3, which is overexpressed in cancers with poor prognosis.
January 1982 in “Clinical Cosmetic and Investigational Dermatology” This case report describes a 54-year-old woman with familial dyskeratotic comedones who experienced slight improvement in her skin lesions after three months of treatment with topical retinoids and urea cream.
June 2019 in “Reactions Weekly” This study found that selective deletion of PIKFyve kinase using a PF4 promoter in mice led to defective platelet lysosome biogenesis and a prothrombotic effect, with unexpected macrophage infiltration in multiple organs.
December 2016 in “Anales del sistema sanitario de Navarra” This case study reports successful treatment of frontal fibrosing alopecia with daily 2.5mg finasteride in a 77-year-old woman.
2 citations
,
September 2021 in “Anais Brasileiros de Dermatologia” Increased sunscreen use may be linked to frontal fibrosing alopecia in Hispanic females.
2 citations
,
August 2021 in “Animal Cells and Systems” This study suggests that egfl6 expression in the pharyngeal pouches is not essential for craniofacial development in zebrafish.
1 citations
,
July 2016 in “British Journal of Dermatology” Men with a certain type of hair loss often use facial moisturizers, and a specific antibiotic treatment may help another hair condition.
11 citations
,
April 2020 in “Journal of Dermatological Treatment” This study found that combining oral isotretinoin with topical treatments was more effective than topical treatments alone for improving frontal fibrosing alopecia symptoms, despite some side effects.
45 citations
,
February 2005 in “Steroids” This study reported that certain newly synthesized steroidal derivatives showed stronger inhibitory activity against the 5α-reductase enzyme than finasteride in hamsters, suggesting their potential as enzyme inhibitors.
8 citations
,
December 2008 in “Journal of The American Academy of Dermatology” This case report describes the first known instance of fixed drug eruption linked to finasteride, confirmed through an oral challenge test that reproduced symptoms at the same skin site.