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In this study, a dual soft drug design strategy improved the AR antagonist candidate 39, showing potent AR antagonism and good safety in a mouse hair-growth model, with similar efficacy to pyrilutamide but faster response.

This study found that the optimized AR antagonist candidate 39, in a hair-growth mouse model, achieved similar efficacy to pyrilutamide with faster onset and favorable safety, suggesting a promising approach for developing topical treatments with low systemic toxicity for androgenetic alopecia.

This study reports that the newly optimized AR antagonist 39 demonstrated effective hair growth and safety in a mouse model of androgenetic alopecia, showing comparable efficacy to pyrilutamide with faster response and favorable pharmacokinetics, due to innovative structural design and dual metabolic inactivation strategy.

In this study, using EMLA cream did not adequately control pain during and after scalp PRP injections for androgenetic alopecia, with anxiety and younger age linked to higher pain levels.

This study examined the use of plant extracts as natural hair dye colourants, highlighting their antioxidant properties and eco-friendly benefits. The authors reported that plant-based dyes effectively deliver vibrant colours and enhance hair health while offering a sustainable alternative to synthetic dyes.

This study found that extracts from plants like onion peel and walnut possess strong antioxidant properties, making them promising eco-friendly alternatives to synthetic hair dyes, delivering vibrant colors and better wash fastness when combined with oxalic acid.

This study evaluated petroleum jelly-based bioactive glass ointments with varying copper concentrations for wound healing in chronic wound models, finding that the 3 wt% copper formulation significantly improved healing by enhancing tissue regeneration, vascularization, and antibacterial protection compared to controls.

In this study, calcium imaging in transgenic mice revealed that non-neuronal TRPV4 in the skin enhances afferent signaling during electrical stimulation, suggesting a role for neuroimmune interaction in acupuncture signal initiation.

This study found that a bioactive borosilicate glass containing Sr and Cu ions exhibited promising mechanical strength, biocompatibility, and antibacterial activity, particularly the CuSr-1 wt.% composition, suggesting potential for use in orthopedic implants and bone tissue engineering.

The device improved hair growth and thickness in men without side effects.

This clinical study found that using a cream or lotion as an additional treatment alongside standard care for atopic dermatitis significantly reduced symptoms and improved skin moisturization and barrier function within 28 days compared to standard care alone in participants with mild-to-moderate eczema.

This review highlights the role of the brain–gut–skin axis in systemic inflammatory skin conditions, revealing potential interventions like microbiome-directed treatments and integrative therapies, though emphasizes the need for more robust clinical validation.

This study developed a method using UHPLC-MS/MS and MSPE to detect trace amounts of sex hormones in cosmetics, finding progestins and estrogens in some products, and performed a preliminary safety evaluation for residual progesterone in hair loss prevention cosmetics.

In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.

This study developed an ultrahigh-power sonicator to improve protein extraction from hair shafts, followed by advanced proteomic analysis, identifying 239 differentially expressed proteins in fetal growth restriction cases compared to healthy controls, which were validated as potential biomarkers for perinatal diagnostics.

This research found that four types of biocompatible nanochitin promoted hair growth in mice, with partially deacetylated and phosphoric acid hydrolyzed nanochitins showing the best results, while amphoteric nanochitin provided the most balanced overall effect.

In this study, researchers found that exosome-like nanoparticles isolated from Polygoni Multiflori Radix can promote hair growth in mice by modulating androgen signaling and gene expression, outperforming Minoxidil in testosterone-induced conditions.

This study reported the development of a pH-responsive microreactor that effectively targets infections by eradicating over 99.9% of MRSA and reprogramming the immune response to promote healing, achieving complete infection clearance and tissue regeneration in a 7-day period.

This study investigated individuals with androgenetic alopecia and found that serum iron and ferritin levels are associated with obstructive sleep apnea severity, suggesting the importance of considering iron profiles in managing the condition.

In this case report and literature review, researchers identified a novel mutation in the CLDN1 gene linked to neonatal ichthyosis-sclerosing cholangitis syndrome and found that its phenotype varies widely, suggesting a multidisciplinary approach is crucial for management.

This study suggests that topical caffeine may be a safe and promising treatment for hair loss, but the researchers highlight the need for more large-scale randomized trials to confirm its efficacy.

In this investigation, acute alopecia was linked to selenium-contaminated wheat in rural Maharashtra, India, following reports of sudden hair loss in 18 villages, with evaluations conducted in Machindrakhed and Bhondgaon.

This study reported discovering a novel missense variant in a case of autosomal recessive woolly hair in a 31-year-old Chinese woman, which significantly reduced secretion of the encoded protein, likely leading to disease by impairing its hydrolytic function.

In this study, microneedling-administered topical cetirizine was observed to significantly enhance hair density and increase vellus hair prevalence in men with androgenetic alopecia, with no notable adverse effects reported.

Early-onset hair loss in Egyptian males is linked to genetics, hormones, and lifestyle factors like smoking and diet.

This study observed that all treatment groups for androgenetic alopecia, using either minoxidil, adipose-derived stem cell secretome, or a combination, showed significant hair growth improvement, with the best results seen in the combination group by week 12, and minimal side effects noted mainly with minoxidil.

In this multicenter Phase II trial, researchers found that topical GT20029 significantly increased hair regrowth in Chinese adult males with androgenetic alopecia compared to placebo, demonstrating good tolerability and suggesting the need for further studies to confirm its therapeutic potential.

This critique of a 2019 study highlights the potential of a liposomal hydrogel for delivering Minoxidil and Tretinoin to treat androgenetic alopecia, but underscores the need for in vivo trials and further stability and interaction analysis to validate its promise.

This review highlights that while dandruff affects over 50% of humans and cannot be fully eradicated, it can be controlled through chemical treatments that may cause side effects or herbal remedies such as Neem and Tea tree oil, which have longstanding use in hair care.

This Phase II trial found that topical GT20029 significantly increased hair count and width at 12 weeks in Chinese men with androgenetic alopecia compared to placebo, with good tolerability and similar adverse event incidence across groups.