Targeted Determination of Residual Sex Hormones in Cosmetics Using Magnetic Solid-Phase Extraction with Isotope-Labeled Internal Standards by UHPLC-MS/MS

    December 2025 in “ Molecules ”
    Yalei Dong, Shuyan Sun, Yasen Qiao … Lei Sun
    Studysummary This study developed a method using UHPLC-MS/MS and MSPE to detect trace amounts of sex hormones in cosmetics, finding progestins and estrogens in some products, and performed a preliminary safety evaluation for residual progesterone in hair loss prevention cosmetics.
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    Research cited in this study 2

    1. Hormonal Therapies in Cosmetic Dermatology: Mechanisms, Clinical Applications, and Future Perspectives Cosmetics · 2025
    2. Simultaneous Determination of Seven Prohibited Substances in Cosmetic Products by Liquid Chromatography–Tandem Mass Spectrometry Chinese Chemical Letters/Chinese chemical letters · 2013