20 citations
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September 1995 in “PubMed” This review discusses the wide range of drugs potentially causing reversible or irreversible hair loss and emphasizes the difficulty of diagnosing drug-induced alopecia without withdrawal of the suspected medication; it reports no new clinical findings.
2 citations
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June 1986 in “Journal of Clinical Pharmacy and Therapeutics” This study demonstrated that certain metal salts can bind to sodium valproate and discussed the potential link to hair loss in patients treated for epilepsy.
March 2024 in “Journal of medicinal plants studies” This review comprehensively examines the Hibiscus rosa-sinensis plant, detailing its distribution, physical and chemical properties, bioactive compounds, ethnomedicinal uses, and potential toxicity, providing a broad understanding of its characteristics and health implications.
11 citations
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April 2018 in “Epilepsy research” This study indicated that administering letrozole to Swiss albino mice may have anticonvulsant effects against kainic acid-induced seizures by inhibiting testosterone aromatization to 17β-estradiol and increasing anticonvulsant metabolites in the hippocampus.
May 2024 in “Brain disorders” In this animal study, agmatine exhibited a protective effect against seizures related to hormone fluctuations, with results suggesting that its anticonvulsant properties may involve interactions with central neurosteroids in female rats experiencing progesterone withdrawal.
This source reviews the traditional and ethnopharmacological uses of Adiantum capillus-veneris Linn (Maidenhair fern), noting its historical applications for ailments such as alopecia and skin disorders, and highlights its modern pharmacological effects, including anticonvulsant and anti-inflammatory properties, confirmed in recent research.
26 citations
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July 2012 in “Epilepsy & Behavior” This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.
24 citations
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November 1978 in “JAMA” This study reports that valproic acid is effective in treating absence seizures and shows improvement in other types of seizures, though about 20% of patients experienced adverse effects.
14 citations
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October 2015 in “Neurochemistry International” This study found that letrozole, an aromatase inhibitor, reduced the incidence and severity of PTZ-induced kindling seizures in mice, potentially due to its effects on 17β-estradiol and neurosteroid synthesis.
March 2023 in “Scientific Reports” In this rodent model study, the researchers reported that using low-intensity focused ultrasound with phenytoin enhanced its anti-epileptic efficacy by disrupting plasma protein binding in a region-specific manner, reducing seizure frequency and duration.
20 citations
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December 2011 in “Journal of inherited metabolic disease” This study found that valproic acid may interfere with the leucine metabolic pathway by inhibiting 3-methylcrotonyl-CoA carboxylase and biotinidase, which could contribute to side effects like skin rash and hair loss in patients.
269 citations
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May 2002 in “Journal of Neuroscience” This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
44 citations
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December 1975 in “Developmental Medicine & Child Neurology” This study found that sodium valproate effectively controlled petit mal seizures in children resistant to other anticonvulsants but was less effective for other seizure types.
2 citations
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October 2022 in “Hop and Medicinal Plants” This review discusses the traditional and potential therapeutic uses of lavender, highlighting its possible anxiolytic and neuroprotective effects, but notes a lack of strong scientific evidence for many claimed benefits.
August 2018 in “Online journal of neurology and brain disorders” This study reported that sodium valproate completely stopped epilepsy in 43% of patients and reduced seizures by 50% in 22% of patients who were resistant to other anticonvulsants.
This study utilized the USFDA AERS to identify significant associations between various medications—such as anti-osteoporotic drugs and phenytoin—and gingival disorders, noting emergent signals with finasteride, COVID-19 vaccine, and levothyroxine, suggesting a need for awareness of oral side effects.
11 citations
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December 2012 in “Alcoholism Clinical and Experimental Research” This study found that in Withdrawal Seizure-Prone mice, ethanol withdrawal decreased the sensitivity of GABA A receptors to GABAergic neurosteroids in certain areas of the brain.
97 citations
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December 2010 in “Journal of Neuroscience” This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.
September 2018 in “Practical diabetes” This review indicates that sodium valproate might benefit diabetic peripheral neuropathy patients, but evidence is limited and inconsistent, so it should be reserved for treatment-resistant cases.
29 citations
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March 1987 in “Therapeutic Drug Monitoring” This study found that venous blood ammonia levels, particularly in patients taking valproate combined with other antiepileptic drugs, were significantly elevated compared to those on valproate alone.
January 2024 in “Arquivos de Neuro-Psiquiatria” This study reviewed various treatments for migraines and found that both classic medications, such as triptans and beta-blockers, and newer options like CGRP inhibitors, are effective, while non-pharmacological approaches provide moderate relief and are highly effective preventively, though accessibility can be an issue.
July 2015 in “Reactions weekly” Lamotrigine can cause hair loss in some patients.
January 2017 in “Elsevier eBooks” This study suggests that progesterone may have a complex role in absence epilepsy, facilitating seizures through conversion to allopregnanolone, but potentially reducing them during pregnancy.
170 citations
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June 1974 in “BMJ” This study found that sodium valproate effectively stopped or reduced seizures in patients with various types of epilepsy, with best results in absence and myoclonic seizures, though it caused temporary hair loss in some cases.
83 citations
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January 2004 in “Pharmacology & Therapeutics” This review explores the potential role of pregnane neurosteroids in modulating alcohol withdrawal symptoms, suggesting a therapeutic target for treating alcohol dependence, but reports no new clinical results.
60 citations
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December 2013 in “PLoS ONE” The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.
This study identified compounds like hexadecanoic acid, alphaspinasterol, and squalene in Cucurbita pepo roots, which may offer new pharmacological approaches for developing therapies for various conditions.
April 2025 in “International Journal of Scientific Research in Science and Technology” This review explores the therapeutic potential and diverse pharmacological properties of the tree Tectona grandis, highlighting its anti-ulcerogenic, antihyperglycemic, antifungal, and other activities, as well as recent advancements in using its extracts for metal nanoparticle synthesis with antimicrobial applications.
February 2023 in “Asian journal of pharmaceutical research and development” This survey reports on the types and extraction factors of flavonoids in three aquatic plants from Iraqi marshlands but notes limited information on individual flavonoid profiles and their biological impacts.
201 citations
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November 2002 in “Annals of internal medicine” This guideline discusses evidence-based recommendations for managing acute migraine attacks and preventing migraines, highlighting effective treatments such as NSAIDs and triptans but reports no new clinical findings.