59 citations
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October 1976 in “Acta Neurologica Scandinavica” This study found that sodium valproate significantly reduced seizure frequency by over 50% in about 70% of patients with generalized seizures but was less effective for partial seizures.
170 citations
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June 1974 in “BMJ” This study found that sodium valproate effectively stopped or reduced seizures in patients with various types of epilepsy, with best results in absence and myoclonic seizures, though it caused temporary hair loss in some cases.
1 citations
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December 1982 in “PubMed” In this study, sodium valproate as monotherapy stopped seizures in 50% of epileptic children and was most effective in primary generalized and photosensitive epilepsies with notable side effects.
44 citations
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December 1975 in “Developmental Medicine & Child Neurology” This study found that sodium valproate effectively controlled petit mal seizures in children resistant to other anticonvulsants but was less effective for other seizure types.
17 citations
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October 1980 in “PubMed” In this study, sodium valproate achieved complete seizure control in 82% of children as monotherapy, with higher plasma levels potentially linked to resistant cases.
This study found that sodium valproate improved seizure control in children with epilepsy, with increased weight gain being the most common side effect reported.