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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Choosing the right patients, using proper techniques, and having thorough knowledge are key to preventing and managing dermal filler complications.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Cancer therapy can cause various skin problems, including hair loss, skin darkening, painful hand-foot syndrome, and severe skin damage.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Improving skin barrier and using antifungal treatments can help manage dandruff.

The document concludes that dandruff and seborrheic dermatitis are linked to inflammation and skin changes, and treating them with specific shampoos can reduce these issues.