Case of Alopecia Universalis Accompanied by Minimal Change Nephrotic Syndrome

A 48-year-old man with a long history of minimal change nephrotic syndrome (MCNS) experienced sudden, complete hair loss across his body, diagnosed as alopecia universalis. Despite various treatments, his renal dysfunction persisted, and his hair loss coincided with a relapse of MCNS. Histological examination revealed increased telogen hair follicles and inflammatory cells around hair follicles, with elevated serum IgE levels and numerous mast cells detected. The study suggested a potential link between MCNS and alopecia universalis, possibly due to similar pathogenic mechanisms involving T lymphocytes, cytokines, and mast cells, although direct evidence was not established.