research Activation of Breast Cancer Cell Proliferation by ROR-Alpha Through Aromatase Promoter
ROR-alpha may increase the growth of certain breast cancer cells by boosting aromatase, which could affect breast cancer prognosis.
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research Androstenedione: Risks and Lack of Efficacy in Athletes
Androstenedione, a hormone supplement, doesn't improve muscle or performance and can cause harmful side effects.
research Scalp Hair 17-Hydroxyprogesterone And Androstenedione As A Long-Term Therapy Monitoring Tool In Congenital Adrenal Hyperplasia
Scalp hair 17-OHP and androstenedione levels can help monitor treatment in CAH patients.
research Effect of a Combination of Ethinylestradiol and Desogestrel in Adolescents with Oligomenorrhea and Ovarian Hyperandrogenism
The treatment temporarily improved symptoms of hyperandrogenism in adolescents.
research Editorial: Androgen-Dependent Diseases And Their Treatment
Continued research and awareness are needed to improve treatments for androgen-dependent diseases.
research A Model for Predicting Polycystic Ovary Syndrome Using Serum AMH, Menstrual Cycle Length, Body Mass Index, and Serum Androstenedione in Chinese Reproductive-Aged Population: A Retrospective Cohort Study
A model using hormone levels, cycle length, and BMI can help identify PCOS in Chinese women but isn't for screening teens.
research Impact of Weight Reduction and Oral Contraceptive Pills on Hyperandrogenism
Losing weight and taking birth control pills can greatly improve severe male hormone excess in women with PCOS.
research Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line
Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
research Optimal Starting Dose of Clomiphene Citrate for Ovulation Induction in Anovulatory PCOS Women
Choosing the right starting dose of Clomiphene Citrate for ovulation induction in PCOS women is challenging; higher BMI and hormone levels may indicate resistance to the standard dose.
research Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne
A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.
research Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone
Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.
research A Comparative Study of a Gonadotropin-Releasing Hormone Agonist and Finasteride on Idiopathic Hirsutism
Both finasteride and GnRH agonist treatments reduced hair growth in women with idiopathic hirsutism, but GnRH agonist was more effective.
research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
research The Influence of ESR1 Polymorphisms on Hormonal, Metabolic, and Mineral Balance Markers in Women with Hyperandrogenism
Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.
research Finasteride Treatment of Premature Androgenetic Alopecia
Finasteride, a hair loss medication, was found to be safe and effective in improving hair quality and stopping hair loss in men with early-onset baldness.
research An Ovarian Leydig Cell Tumor Undetected by Ultrasound in a Postmenopausal Woman with Hirsutism and Hyperandrogenism
A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.
research Rare Presentation of Precocious Puberty Secondary to LH-Secreting Adenoma
An 8-year-old boy's early puberty was caused by a rare hormone-secreting brain tumor, which was successfully treated with surgery.
research British Menopause Society Tools for Clinicians: Testosterone Replacement in Menopause
Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.
research Aldosterone- and Cortisol-Cosecreting Adrenal Adenoma, Ovarian Hyperthecosis, and Breast Cancer
The conclusion is that thorough investigation of hypertension and hormonal dysfunctions is important, and there may be a link between these conditions and cancer.
research Sexual Function in Women with Androgen Excess Disorders: Classic Forms of Congenital Adrenal Hyperplasia and Polycystic Ovary Syndrome
Women with congenital adrenal hyperplasia (CAH) have more sexual function issues than those with polycystic ovary syndrome (PCOS), but physical activity can improve sexual functioning in all women.
research Prostaglandin D2-Enhanced Testosterone Metabolism in Human Keratinocytes Is Mediated by Reactive Oxygen Species
Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.
research Sexual Function and Depressive Symptoms in Young Women With Nonclassic Congenital Adrenal Hyperplasia
Young women with nonclassic congenital adrenal hyperplasia may experience worse sexual function and mild depression compared to healthy women.
research Finasteride Treatment for One Year in 35 Hirsute Patients
Finasteride safely reduces excessive hair growth in women.
research Clinical and Hormonal Evaluation of Androgen Excess
Most cases of high male hormone levels in women are due to polycystic ovary syndrome.
research A Detailed Investigation of Hirsutism in a Turkish Population: Idiopathic Hyperandrogenemia as a Perplexing Issue
The main cause of excessive hair growth in Turkish women is Polycystic ovary syndrome, but in about one fifth of cases, the reason for high male hormone levels is unknown.
research Is The Metabolism Of Testosterone To 5α-Dihydrotestosterone Required For Androgen Action In The Skin?
Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.
research Drugs Affecting Hair Growth
Different hair growth phases affect how follicles respond to X-rays, and hormones like testosterone and dihydrotestosterone play a key role in baldness; transplanted hair can grow on bald scalp areas.
research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ
Sex hormones, especially androgens, play a key role in causing acne.
research Ovarian Hyperthecosis as a Cause of Hypersexualization in a Post-Menopausal Female
Ovarian Hyperthecosis caused hypersexuality in an older woman and was successfully treated with surgery.
research The Evaluation of Endothelial Function with Flow-Mediated Dilatation and Carotid Intima Media Thickness in Young Nonobese Polycystic Ovary Syndrome Patients; Existence of Insulin Resistance Alone May Not Represent an Adequate Condition for Deterioration of Endothelial Function
Insulin resistance might not be enough to worsen blood vessel function in young, nonobese women with polycystic ovary syndrome.