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The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

Women with PCOS have higher levels of AMH in their blood and follicles, and this can help predict their risk of overreaction to fertility treatments.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.

Diagnosing PCOS in teenage girls is tricky and requires careful evaluation and management.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Testosterone's role in women's sex drive is unclear and needs more research, as low levels don't always mean less sexual interest and high levels can cause side effects.

Pattern baldness is likely caused by a dominant gene influenced by testosterone levels, making it more common in men.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

Bee venom might be a good alternative treatment for various skin conditions because it has many healing properties.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Higher hs-CRP levels in Indian adolescent women with PCOS are more related to BMI than PCOS itself.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

A woman with Cushing's syndrome improved after surgery to remove a tumor causing the condition.

Menopause often leads to lower sexual desire and discomfort during sex, but treatment should be personalized and only if it bothers the woman.

New partnerships, clinical trials, and drug approvals marked progress in therapeutic delivery in July 2018.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

The document concludes that transsexual individuals often experience improved quality of life after transitioning, despite higher risks of psychiatric issues and mortality.