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Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

SHBG binding properties are unchanged in male liver cirrhosis patients.

The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.

Androgens may worsen COVID-19 and hair loss could indicate the disease's severity.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Baldness caused by male hormones in female-to-male transsexuals doesn't increase the risk of heart disease.

Women with PCOS have unhealthy changes in their cholesterol particles that are not related to their body weight.

Certain gene variations are linked to higher male hormone levels in Chinese women with PCOS and insulin resistance.

Hair loss is linked to insulin resistance in women, regardless of hormone levels.

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.

Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.

Early balding, premature graying, and hair thinning can predict heart disease in young Asian males.

High aldosterone and free testosterone levels link to female hair loss; testing aldosterone may predict hypertension risk.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

Children receive less than half of recommended health care, and routine hormonal testing for female-pattern hair loss is unnecessary without other androgen excess symptoms.

The document concludes that the androgen receptor's structure and function are complex, affecting how it regulates genes and is involved in diseases like prostate cancer.

Menopausal women have higher androgen levels, which can cause symptoms like facial hair growth and low sexual desire.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

Anti-androgen drugs can help reduce OCD symptoms, but more large-scale trials are needed to confirm their effectiveness.