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Finasteride doesn't improve survival in LNCaP tumor model during off-cycle of therapy.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Flutamide and finasteride reduced sex hormones in pregnant hyenas, but increased them in males.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.

Androgen deprivation therapy doesn't lower the risk of death from COVID-19 in prostate cancer patients.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Different anti-androgen medications can help treat excessive hair growth, but the right choice depends on accurate diagnosis.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Certain hormone treatments can improve acne and related conditions in women.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

Antiandrogen treatments combined with oral contraceptives can help manage hair growth and hair loss in women with PCOS.

Spironolactone improved blood vessel function and cholesterol levels in non-obese women with PCOS.

Spironolactone plus finasteride reduces hirsutism more effectively.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Androgens, like testosterone, are crucial for early testicular descent in rats.

The document concludes that various cosmetic and drug treatments are available for hirsutism, and some new drugs show promise.