research FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects
FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
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research Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite
Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells In Vitro by Forming a Complex With Tcf4 and β-Catenin
Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.
research Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates
The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.
research Serum AMH Levels in the Differential Diagnosis of Hyperandrogenemic Conditions
Blood AMH levels are higher in women with PCOS than in those with other similar conditions.
research Integration Analysis of Transcriptome and Proteome Reveals the Mechanisms of Goat Wool Bending
The research identified key proteins and genes that may influence wool bending in goats.
research Can AMH Levels Distinguish LOCAH from PCOS Among Hirsute Women?
AMH levels can't reliably tell the difference between LOCAH and all types of PCOS in women with excessive hair growth.
research Environment of the Anagen Follicle
The document concludes that hair follicles have a complex environment and our understanding of it is growing, but there are limitations when applying animal study findings to humans.
research Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study
Father's finasteride use may affect son's fertility and testicular function.
research Ovarian Leydig Cell Hyperplasia as a Rare Cause of Hair Loss in a Postmenopausal Female Patient: A Case Report and Diagnostic Approach Toward Postmenopausal Hyperandrogenism
An 84-year-old woman's hair loss was due to a rare condition called Leydig cell hyperplasia, which was treated with surgery.
research Phytochemicals: An Herbal Remedy for Alopecia
Plant-based treatments can effectively and safely treat hair loss.
research Signaling Pathways in Hair Aging
Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.
research An Update on Etiopathogenesis and Management of Alopecia
Personalized treatment plans combining natural and synthetic approaches are important for managing alopecia effectively.
research Effect of Testosterone, Dihydrotestosterone, Estradiol, and Cortisol on the Quality of Fresh and Cryopreserved Stallion Sperm
Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.
research Prevalence of Polycystic Ovary Syndrome in Unselected Women from Southern China
Many women in southern China have polycystic ovary syndrome, with some symptoms differing from Western women.
research Targeting the Pre-Receptor Metabolism of Cortisol as a Novel Therapy in Obesity and Diabetes
Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.
research High Prevalence of Chronic Thyroiditis in Patients with Polycystic Ovary Syndrome
People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.
research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients
Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.
research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland
Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.
research Analysis of Protein Interactions by Surface Plasmon Resonance
Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.
research BMI and Levels of Zinc, Copper in Hair, Serum, and Urine of Turkish Male Patients with Androgenetic Alopecia
Lower hair zinc and copper levels found in Turkish males with hair loss; higher BMI linked to less hair zinc.
research Epidemiology of Hirsutism Among Women of Reproductive Age in the Community: A Simplified Scoring System
A simplified scoring system can effectively diagnose hirsutism in Chinese women of reproductive age.
research Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Visceral and Subcutaneous Adipose Tissues of Patients with Polycystic Ovary Syndrome Is Associated with Adiposity
Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.
research Role of 5α-Dihydrotestosterone in Testicular Development of Gilthead Seabream Following Finasteride Administration
DHT affects testicular development and regulates spermatogenesis in some fish.
research The Differences Between Aromatizable And Non-Aromatizable Androgens In Relation To Body Composition And Metabolic Syndrome Risk Factors In Men
Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.
research 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro
11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
research Alterations in Nasal Mucociliary Activity in Polycystic Ovary Syndrome
Women with PCOS may have a higher risk of respiratory and ear infections due to slower nasal mucociliary clearance.
research Two Cycles of ABVD Followed by Involved Field Radiotherapy with 20 Gray Is the New Standard of Care in the Treatment of Patients with Early Stage Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group Trial HD10
Two cycles of ABVD chemotherapy followed by 20 Gy radiotherapy is the new standard for early-stage Hodgkin lymphoma due to lower toxicity and similar effectiveness.
research Acyl-CoA Binding Protein and Epidermal Barrier Function
ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.
research Characterization of DNA Methylation and Screening of Epigenetic Markers in Polycystic Ovary Syndrome
DNA methylation changes in women with PCOS could be used as disease markers and suggest new treatment targets.