December 1990 in “PubMed” This study found that topical application of 17 alpha-propylmesterolone significantly increased proliferative activity in hair matrix cells in men with androgenetic alopecia.
In this study, researchers explored the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb and discovered unexpected subpopulations of melanocytes, including immature SOX10-negative cells, highlighting potential non-melanogenic roles or transitional migratory functions that require further investigation.
August 2023 in “International Journal of Molecular Sciences” This study observed unexpected heterogeneity among pigment cells in human scalp hair follicles, identifying immature melanocyte populations outside traditional pigment production zones, raising questions about their potential roles beyond melanin synthesis.
12 citations
,
June 2009 in “Journal of Cosmetic Dermatology” This study reports the first cases of loose anagen hair syndrome in dark-skinned children from Upper Egypt, noting it may be under-diagnosed and primarily causes cosmetic concerns without affecting general health.
1 citations
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July 2019 in “Case reports in dermatology” This case report describes the first known instance of loose anagen hair syndrome in a Southeast Asian child, a 13-year-old Thai boy with hair thinning and excessive shedding on the frontal scalp.
This review discusses loose anagen hair syndrome in children, characterized by non-scarring alopecia and increased hair shedding, and reports no new results; topical minoxidil may be used as a treatment.
1 citations
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August 1994 in “Journal of Cutaneous Pathology” This study found that matrix cells from normal hair follicles primarily had a 2C DNA content, while those in androgenetic alopecia showed a significant increase in cells with a higher DNA content.
109 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.
28 citations
,
January 2007 in “Dermatology” This article discusses the presentation of chemotherapy-induced anagen effluvium as either diffuse or patterned hair loss and reports no new clinical findings.
25 citations
,
October 1975 in “Journal of Cutaneous Pathology” This study found that in alopecia areata, hair bulbs are blocked in an early growth stage due to impaired metabolic function in the surrounding connective tissue, hindering hair growth.
22 citations
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July 1990 in “Acta Dermato Venereologica” In this study, high concentrations of dihydrotestosterone and testosterone reduced the growth of human hair follicle cells in vitro, while high estradiol levels increased their growth.
13 citations
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August 2007 in “Journal of Investigative Dermatology” Mouse hair can regrow in a special lab setup without serum.
8 citations
,
July 2007 in “International Journal of Dermatology” Using 5% topical minoxidil improved and normalized the hair growth in a girl with short anagen hair naevus.
7 citations
,
June 1967 in “Journal of Investigative Dermatology” This study reports an unusual finding of plucked anagen hairs with intact hair papilla and connective tissue sheath in various scalp disorders, suggesting further documentation is needed.
4 citations
,
April 2018 in “The journal of pediatrics/The Journal of pediatrics” This case report discusses a 6-year-old girl with loose anagen hair syndrome, characterized by painlessly shedding hair, and notes no evidence of benefit from biotin supplementation.
3 citations
,
January 2005 in “Biological & Pharmaceutical Bulletin” This study reports that the peptide GPIGS, found in Bacillus sp. M18 conditioned medium, may promote hair growth through the PI-3K/Akt pathway and accelerate hair regrowth in mice.
December 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This entry does not provide an abstract or new research findings, so no specific results are available for summary.
February 2010 in “Journal of The American Academy of Dermatology” Mimicking growth factors in a topical solution can prolong hair growth phase and reduce hair loss without side effects.
130 citations
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December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, different types of catagen in the C57BL/6 mouse model exhibited varying effects on hair follicle melanocytes and melanin distribution, with spontaneous and dexamethasone-induced catagen showing pigment incontinence, while cyclophosphamide-induced catagen retained dendritic melanocytes but increased ectopic melanin.
19 citations
,
February 1998 in “Cellular Immunology” Hair growth phase in mice weakens certain immune responses.
March 2024 in “Tissue and cell/Tissue & cell” This study found that in human hair bulbs, telomerase is present mainly in the nuclei of cells undergoing proliferation, particularly in the matrix epithelium during the anagen phase, and sparsely in the outer root sheath during late catagen and telogen phases.
19 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This study observed that human hair follicles with a completely destroyed bulb can regenerate after being grafted onto immunodeficient mice, entering a shortened dystrophic telogen followed by anagen phase.
6 citations
,
November 2013 in “International Journal of Radiation Biology” In this study, γ-ray irradiation of mice reduced hair follicle density and pigmentation, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.
3 citations
,
April 2016 in “Food Science and Biotechnology” This study found that Oriental melon leaf extracts promoted hair growth in a mouse model and cultured human hair follicles, suggesting potential use as a treatment for hair loss.
July 2024 in “Journal of Investigative Dermatology” Ashwagandha nanoparticles help hair grow by increasing a growth factor.
November 2013 in “Institutional Repositories DataBase (IRDB)” In this study, γ-ray exposure in mice decreased hair follicle density and pigmentation, suggesting damage to stem cells affecting hair follicle regeneration.
November 2013 in “Institutional Repositories DataBase (IRDB)” In this study, γ-ray irradiation in mice during the first telogen phase led to decreased hair follicle density and pigmentation anomalies, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.
April 2017 in “Journal of Investigative Dermatology” This study observed that a 3D culture model of hair follicle cells showed an anagen-like phase between days 3 to 6 and transitioned to a catagen-like phase by day 7, highlighting cell differentiation and structural development over time.
19 citations
,
April 2015 in “International Journal of Molecular Sciences” This study identified distinct gene expression patterns in wool follicle bulbs that may play important roles in wool follicle cycling and regeneration in sheep.
14 citations
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October 2020 in “Scientific reports” This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.