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This study found that the peptides RMYYY and VMYMI displayed stronger binding energy and more frequent interactions with HPGDS compared to the native inhibitor, suggesting potential as future therapeutic drugs.

The researchers reported that Gambogic Amide may prevent hair greying and promote hair growth by maintaining follicle pigmentation in vitro through activation and migration of melanocytes.

This study found that early diagnosis using gas chromatography/mass spectrometry and appropriate long-term treatment are crucial for improving outcomes in patients with methylmalonic acidemia.

This study found that hydroalcoholic extracts of Trigonella foenum-graecum L. seeds were rich in bioactive phytochemicals and demonstrated potential therapeutic properties against dandruff, alopecia, and oxidative stress through molecular docking analysis of key constituents such as diosgenin, kaempferol, and quercetin.

This study found that a more liberal intake of restricted amino acids in patients with methylmalonic acidemia resulted in improved growth and fewer illness episodes.

The authors concluded that liver transplantation in children with propionic acidemia can reduce the risk of metabolic decompensation and enhance quality of life, although some metabolic issues may persist.

This review outlines computational strategies, including chemogenomics and drug repositioning, for coronavirus drug discovery and reports no new clinical findings; the authors highlight the advantages of these methods in rapidly identifying therapeutic candidates.

This study designed a 66 K SNP chip using solution hybrid selection for cashmere goats, reporting SNP call rates between 95.3% and 99.8% and demonstrating its utility in genomic analyses, suggesting potential application for other species.

In this study, researchers validated a computational workflow for repurposing non-antibacterial drugs as antibacterial agents and highlighted daprodustat, combined with an efflux pump inhibitor, as a promising strategy against bacterial pathogens.

This study introduced Cadd4, a peptide-based degrader developed using computer-aided drug design, which effectively reduced PCSK9 levels and increased LDL receptor expression, resulting in decreased plasma cholesterol and LDL-C levels in hypercholesterolemic mice, without liver toxicity.

In this study, researchers highlighted the integration of computational technology with nanozyme research, enabling atomic-level kinetic analysis and improved design and synthesis of nanozymes, while enhancing detection methods through automated, accurate, and reproducible analyses.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This study found that polyamidoamine dendrimers can permeate skin's current conducting pores and alter the magnitude and direction of electroosmotic flow, affecting drug flux during iontophoresis.

This study identified compounds 11d and 11k as potential dual 5α-reductase inhibitors and AR antagonists with significant anti-proliferative effects on prostate cancer cell lines, suggesting they may offer therapeutic value.

In this study, the novel thiol-Michael click perming molecule, MA2-CySS, achieved repeatable perming with reduced oxidative damage, preserving hair keratin's structure while maintaining efficiency comparable to traditional oxidative methods.

This article presents a case of congenital adrenal hyperplasia and myelolipoma in a 56-year-old woman, describing her symptoms and characteristics without offering new clinical results.

This study found that water-soluble beehive extract exhibited anxiolytic, antidepressant, and anti-inflammatory effects in animal models.

This review highlights the potential benefits of spironolactone in dermatology, particularly for female acne, supporting its safety over long-term use without extensive testing, but presents no new clinical results.

In this study, researchers used three-dimensional reconstruction to show that the shape of the hair follicle determines the hair's form, with variations observed among different racial groups.

In this study, chemical treatments during permanent hair straightening were found to randomize proteins in the cortex, aiding in the reconnection of disulfide bonds during oxidation.

This study explored how modifying the 8-substituent of 8-bromobenzoquinolinone affects its selectivity in inhibiting both 5 alpha-reductase isozymes in the scalp.

This article describes the efficient synthesis of (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide, a novel topical antiandrogen, with high purity and enantiomeric excess but reports no pharmacological results.

In this study, formulations of a typical lotion shampoo with ethanol or propylene glycol increased the in-vitro release rate of zinc pyrithione, an anti-dandruff agent.

In this study, combined treatment with transglutaminase and keratin significantly repaired damaged hair by improving its structural properties, reducing swelling, and enhancing crosslink activities, as evidenced by microscopy and spectroscopy analyses.

This study found that hair from ovarian teratomas shares similar chemical composition and morphology with scalp hair, but differs in physical properties and cysteic acid bands.

This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.

This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.

This chapter reviews various chemical synthesis methods for pharmaceutical compounds and reports no new experimental results.

This study developed a new method for synthesizing finasteride that eliminates the need for expensive and toxic chemicals, achieving high purity and a 24.2% yield.