26 citations
,
September 2013 in “Journal of Dermatological Science” In this study, researchers found that serum granulysin levels might serve as a novel marker for disease activity in acute alopecia areata, being significantly associated with broader bald skin areas, poorer prognosis, and co-existing allergic disorders.
4 citations
,
March 2007 in “Annales de Dermatologie et de Vénéréologie” This review discusses the adverse effects of hair care products, highlighting irritation dermatitis and allergic contact eczema due to common allergens like paraphenylenediamine and glycerol monothioglycolate, but reports no clinical results.
1 citations
,
June 2025 in “Journal of Patient Experience” This study found that Finnish individuals with alopecia areata, especially those with significant hair loss, reported reduced well-being and significant comorbidities, highlighting unmet needs for treatment and professional support.
April 2018 in “Veterinary Pathology” This study describes a form of lymphocytic mural folliculitis in tigers causing hair loss, concluding it may represent a nonspecific hypersensitivity reaction distinct from T-cell lymphoma.
This review highlights that hair care products can cause adverse effects like irritation dermatitis and allergic contact eczema but does not report new clinical findings.
36 citations
,
June 2015 in “International journal of toxicology” This study established a new mouse model for TCE-induced skin sensitization and reported that proinflammatory cytokines TNF-α, IFN-γ, and IL-2 significantly contribute to this sensitization process.
124 citations
,
January 2012 in “Journal of Allergy and Clinical Immunology” This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.
25 citations
,
November 2020 in “Cell Reports Medicine” Developing human skin has immune cells with memory-like features.
21 citations
,
July 2001 in “Clinics in dermatology” This review discusses the clinical use of nutraceuticals for skin aging in dermatological practices and reports no new clinical results.
1 citations
,
May 2017 in “Journal of The American Academy of Dermatology” In this study, increasing cases of allergic contact dermatitis in Bulgaria were linked to the use of natural products like propolis and marigold.
1 citations
,
May 2017 in “Journal of The American Academy of Dermatology” This study found that the increasing use of natural products like propolis and calendula officinalis in Bulgaria is linked to a growing number of allergic contact dermatitis cases, predominantly in women.
1 citations
,
January 2023 in “Elsevier eBooks” This review discusses the role of phospholipases in skin and hair health, suggesting that understanding their molecular control could inform new treatments for related conditions, but it presents no new clinical results.
July 2026 in “Journal of Investigative Dermatology” Alopecia totalis/universalis involves more intense immune activity and inflammation than patchy alopecia areata.
January 2026 in “JCEM Case Reports” The researchers reported a case of a 51-year-old woman with primary hypothyroidism who developed anaphylaxis to intravenous levothyroxine after being unresponsive to oral formulations, highlighting potential allergic reactions to IV treatments in such patients.
In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.
April 2024 in “Indian Journal of Paediatric Dermatology” This study in Singapore found that alopecia areata generally does not significantly impact the quality of life for pediatric patients and their families, with better outcomes observed in those with comorbidities like allergic rhinitis.
This study evaluated interleukin-26's antimicrobial activity in Hidradenitis Suppurativa and explored its potential role in chronic skin inflammation.
May 2017 in “Journal of The American Academy of Dermatology” This study reported an increase in allergic contact dermatitis cases linked to natural products, particularly propolis and marigold, with a higher incidence in women than men.
February 2026 in “PubMed” This study reported that para-phenylenediamine and toluene-2,5-diamine are the main sensitizers in hair dye-related allergic contact dermatitis, with significant cross-reactivity to several other compounds.
November 2023 in “Journal of Investigative Dermatology” This research investigated immune cell involvement in various types of inflammatory alopecia by analyzing gene expression data from scalp samples, revealing distinct cellular changes in conditions like Alopecia Areata, Frontal Fibrosing Alopecia, Lichen Planopilaris, and Central Centrifugal Cicatricial Alopecia, which may inform future therapeutic targets.
February 2015 in “Rivm (National Institute for Public Health and the Environment)” This report summarizes data from The Netherlands' cosmetovigilance system from 2009-2014, finding that facial and hair products commonly caused undesirable skin reactions like erythema and itching, with severe cases occasionally involving hair loss and respiratory issues.
12 citations
,
May 2019 in “Journal of cosmetic dermatology” This review explores the factors contributing to premature graying of hair, highlighting the role of genetic and environmental influences such as oxidative stress, and discusses potential interventions like diet and herbal remedies, while noting the limitations of common treatments like hair dyes.
11 citations
,
June 2018 in “Annales de dermatologie et de vénéréologie” This narrative review discusses adverse reactions associated with hair care products, specifically irritation dermatitis and allergic contact eczema, and suggests the need for attention to common allergens like PPD, GMTG, and ammonium persulphate.
70 citations
,
June 2023 in “International Journal of Molecular Sciences” In this review, researchers explored how air pollutants increase oxidative stress and inflammation in human skin, affect vitamin D synthesis, and interact with the skin microbiota, also discussing AhR/Nrf2 as a potential target for treating pollution-related skin conditions.
41 citations
,
July 2019 in “Clinical Cosmetic and Investigational Dermatology” This paper explores the complex immune processes and cellular diversity that enable the skin to heal and resist invasion, and highlights its potential as a model for studying regeneration.
30 citations
,
February 2023 in “Journal of Investigative Dermatology” OX40-targeted therapies may help treat skin diseases by reducing inflammation and balancing immune responses.
23 citations
,
December 2021 in “Frontiers in Immunology” This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.
12 citations
,
November 2024 in “Burns & Trauma” This review highlights the critical role of neuroregulation in skin wound healing, emphasizing how neurotransmitters and neuropeptides regulate inflammation, angiogenesis, and cell proliferation, and discusses potential therapeutic strategies, such as neuromodulation, to enhance these processes.
2 citations
,
January 2023 in “Frontiers in Veterinary Science” This study found that although Stephanofilaria infection worsens buffalo fly lesion severity, other factors like bacterial infection and hypersensitivity to buffalo fly feeding also play significant roles.
142 citations
,
March 2019 in “Molecules/Molecules online/Molecules annual” This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.