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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The Rotterdam Study aims to understand various diseases in older adults.

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

Hair and wool have complex microscopic structures with microfibrils and varying cystine content.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Researchers created human hair follicles using a new method that could help treat hair loss.

Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Fluoxetine was not effective in treating hair-pulling disorder in the short term.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.