September 2016 in “Springer eBooks” This review discusses how physical appearance, including skin, facial features, and physique, is linked to aging and health risks, but reports no new experimental results.
June 2026 in “Journal of Investigative Dermatology” Aging weakens sweat glands due to reduced support from immune cells, but treatments may help restore function.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study presented a reproducibility package supporting an exploratory secondary analysis of miRNA dysregulation and aging-related target enrichment in female pattern hair loss, based on a comparison of three scalp samples from affected women to five healthy controls using public dataset GSE106780.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers conducted an exploratory re-analysis of miRNA dysregulation and aging-related target enrichment using publicly available data on female pattern hair loss, comparing 3 FPHL scalp samples to 5 healthy female controls, and emphasized that the findings are preliminary and require further validation.
March 2026 in “Ageing Research Reviews” This review highlights the complex interplay between intrinsic and extrinsic factors influencing skin aging, emphasizing the need for advanced human-specific models to study aging mechanisms and develop new therapies.
March 2026 in “Aging Research” This review provides a comprehensive synthesis of skin aging research, highlighting the interplay of genetic and environmental factors, cellular mechanisms, and advances in diagnostic and therapeutic strategies, while also addressing current debates and future directions in the anti-aging field.
January 2026 in “Aging and Disease” This study highlights the critical role of mitochondria in skin aging and wound repair, suggesting that targeted interventions such as antioxidants, NAD⁺ boosters, and NRF2-based therapies may enhance mitochondrial function and improve cutaneous health.
October 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers found that cochlear hair cell function declined with age in CBA/CaJ mice starting at 10 months, before detectable hearing loss, and was marked by a decrease in cell size and BK channel currents, without effect on MET currents.
March 2025 in “Aging Cell” In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.
November 2023 in “Experimental Dermatology” In this study, researchers found that exosomes derived from dermal sheath cup cells (Exo DSCCs) improved proliferation, viability, and migration while reducing apoptosis in senescent dermal papilla cells, also enhancing hair follicle reconstruction and suggesting a potential strategy for combating senile alopecia.
July 2023 in “AYUSHDHARA” This article examines the Ayurvedic perspective on the aging process, detailing how physical, emotional, and metabolic changes occur naturally over time, affecting various body systems, and highlights the role of Vayu dosha during the final stage of life, Vriddhavastha.
April 2023 in “Journal of Investigative Dermatology” This study presents a new long-term 3D skin model using cells from mature donor skin, showing significant features of skin aging, such as decreased cellular proliferation and hyaluronan content.
October 2022 in “Frontiers in Cell and Developmental Biology” Aging skin is affected by inflammation, reduced stem cell function, and slower wound healing.
January 2019 in “Elsevier eBooks” Skin aging helps us understand overall aging.
August 2018 in “Journal of The American Academy of Dermatology” Aging significantly affects the hair and scalp of nonbalding Caucasian women, with changes that differ from male pattern baldness.
September 2014 in “Springer eBooks” Aging causes hair to gray and thin, with the timing of graying varying by race, and factors like oxidative stress and genetics can lead to hair loss.
This review discusses the processes contributing to hair and scalp aging, noting oxidative stress as a key factor, and reports no new clinical findings.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” This review summarizes major surveys on Behcet's disease, highlighting its systemic manifestations, with primary morbidity linked to ocular involvement causing severe vision loss or blindness.
July 2023 in “Ageing & Longevity” This review discusses two approaches to address aging: a tactical method to delay and slow age-related issues, and a strategic method aiming to eliminate aging altogether by targeting its root cause.
January 2017 in “Journal of Cosmetics, Dermatological Sciences and Applications” Among Chinese women, this study observed that hair density decreases and scalp erythema increases with age, with most aging features like hair diameter and sebum content peaking in their 40s.
January 2017 in “Chemistry & Industry” Eating fewer calories may slow aging and removing old cells can increase lifespan in mice.
20 citations
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August 2020 in “Advances in respiratory medicine” This review discusses the role of risk factors like age and obesity in COVID-19 severity and mortality but notes that current evidence remains weak and requires further study.
June 2020 in “IP Indian journal of clinical and experimental dermatology” This observational study reported that primary ageing dermatoses were more common than non-ageing dermatoses among elderly patients, especially among those with pre-existing skin conditions.
210 citations
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May 2006 in “The FASEB journal” This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.
180 citations
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January 2003 in “American Journal of Clinical Dermatology” This article reviews the effects of menopause on skin aging and suggests that hormone replacement therapy may help reverse some of these changes.
158 citations
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June 2017 in “Maturitas” This review discusses the role of estrogen deficiency in post-menopausal skin aging and wound healing, highlighting opportunities for developing estrogen receptor-targeted therapies and reports no new clinical results.
150 citations
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April 2013 in “Dermato-endocrinology” This review discusses the effects of estrogen on skin aging and highlights potential therapies, but reports no new clinical findings.
132 citations
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January 2017 in “International Journal of Molecular Sciences” This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.
122 citations
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April 2020 in “American Journal Of Pathology” This review discusses the multiple factors contributing to skin aging, including cellular changes and environmental influences, and highlights its recognition as a disease with significant implications beyond cosmetic concerns, without reporting new research results.
120 citations
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October 2007 in “Clinical Interventions in Aging” This review discusses the effects of estrogens on skin aging and highlights the potential benefits of estrogen replacement therapy and selective estrogen receptor modulators for improving skin health in postmenopausal women, but reports no new clinical findings.