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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

Estrogen therapy can reduce skin aging but has cancer risks.

Different types of polycystic ovary syndrome (PCOS) have varying severity, with Type I being the most severe and common.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

Eflornithine cream effectively reduces women's unwanted facial hair but hair returns if treatment stops.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

Lowering testosterone speeds up wound healing in male mice.

DHT may increase the risk of heart disease and death in elderly men.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

The definition of Polycystic Ovary Syndrome may change with new research, and careful screening is key for managing the condition.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

Prolactin affects hair growth cycles and can cause early hair follicle regression.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Women with PCOS are more likely to suffer from depression, anxiety, and stress.

The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Spironolactone can cause side effects like irregular bleeding, but lower doses may reduce these effects and still improve hirsutism.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.