May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” The investigators highlighted Roota Hair Growth as a promising botanical solution for hair concerns, suggesting it may improve hair health by addressing the root causes of thinning, breakage, and scalp fatigue.
September 2025 in “Journal of Natural Remedies” This review article concluded that certain herbal remedies targeting 5-alpha reductase inhibitors may prevent hair loss in androgenetic alopecia by blocking dihydrotestosterone production, although standardizing the concentration of active herbal compounds remains a challenge.
September 2022 in “The American Journal of Dermatopathology” This study found that IL-17 expression was significantly higher in perifollicular fibrosis of active Lichen planopilaris lesions, suggesting that targeting IL-17 could impact the disease's progression.
July 2026 in “Scholars Journal of Medical Case Reports” This case study reports a rare coexistence of alopecia areata and lichen planopilaris in a 37-year-old woman and highlights the importance of targeting active scalp areas for biopsy to appropriately manage coexisting scarring and non-scarring alopecias, with distinct therapeutic priorities.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that combining Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract may help improve hair growth and anchorage by targeting specific signaling pathways in human dermal papilla cells.
23 citations
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January 2018 in “Elsevier eBooks” This chapter reviews formulation principles for creating cosmetic nanoemulsions and applications targeting skin and hair care, but does not present new experimental results.
1 citations
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December 2022 in “Bioactive Materials” In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.
November 2024 in “Rheumatology Advances in Practice” In this case report, the use of ocrelizumab in the second trimester of a high-risk pregnancy with active juvenile-onset systemic lupus erythematosus resulted in a successful birth without complications, although its safety in pregnancy remains unlicensed and further evaluation is needed.
January 2008 in “Deep Blue (University of Michigan)” This study found that Hedgehog-driven skin tumorigenesis is dependent on the Wnt/beta-catenin signaling pathway and suggests that targeting Wnt ligands could be a potential therapeutic strategy.
9 citations
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August 2024 in “Pharmacological Reviews” This review summarized advancements in intestinal lymphatic drug delivery, emphasizing the evolving understanding of lymphatics as active players in health and disease, which has led to innovative therapeutic strategies and enhanced pharmacokinetic outcomes via this delivery route.
4 citations
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June 2023 in “Pharmaceutical Biology” This study found that the Qing Cuo Formula significantly reduced serum androgen and inflammatory cytokine levels in hamsters with damp-heat acne and identified potential molecular mechanisms and active compounds involved.
15 citations
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January 2014 in “Medicinal chemistry” This study conducted molecular docking and ADME property analysis on 144 newly designed isatin analogs, suggesting they exhibit lead-like properties for targeting EGFR enzymes.
1 citations
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November 2018 in “Therapeutic Delivery” This industry update reports on various advancements in therapeutic delivery during July 2018, highlighting active mergers, collaborations, and potential developments across fields like gene therapy, immuno-oncology, and rare diseases treatment; however, no new clinical results are presented.
April 2025 in “Biomacromolecules” This study developed microneedles loaded with Platycladus orientalis leaf extract to treat androgenic alopecia, finding that they can effectively deliver active ingredients into the dermis, promote hair follicle growth by removing free radicals, and activate the Wnt/β-catenin pathway.
January 2024 in “Authorea (Authorea)” This source suggests that convalescent plasma therapy may interfere with early immune responses in COVID-19 due to exosomes suppressing immune cell activity, but proposes it could potentially help with COVID-19 Long Hauler Syndromes by targeting diverse antigen responses beyond just the spike protein.
38 citations
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September 2014 in “Cell and Tissue Research” This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.
23 citations
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May 2020 in “Cell Death and Disease” This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.
1 citations
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September 2025 in “Molecules” This study comparatively evaluated different extraction techniques for Schinus terebinthifolius Raddi leaf extracts and found that conventional extraction with ethanol yielded the highest antioxidant activity and beneficial effects on skin cell viability, supporting its potential use in sustainable cosmeceutical formulations targeting skin aging.
559 citations
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October 2020 in “Frontiers in Molecular Biosciences” This review reports on the current state and potential of solid lipid nanoparticles for drug delivery, emphasizing their safety, biocompatibility, and ease of production, and highlights challenges in translating them to clinical practice, including active clinical trials.
July 2026 in “Más dermatología” This study, published in "Más Dermatol," explores how multiple factors contribute to hair loss, such as genetics, hormones, oxidative stress, microinflammation, and emotional stress, and highlights interventions targeting these causes to improve hair regrowth and quality of life.
April 2026 in “Antioxidants” In this study, broccoli sprout extract and sulforaphane were found to reduce cell viability, suppress growth, and induce apoptosis in breast cancer cells, and oral broccoli sprout extract inhibited tumor growth in animal models, suggesting it may be effective in managing breast cancer.
January 2024 in “Research Square (Research Square)” This study identified key genes related to ischemic stroke through the ferroptosis pathway and highlighted the potential role of specific traditional Chinese medicines in regulating associated biological processes.
474 citations
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January 2012 in “Chemistry & biology” This review discusses the discovery and potential therapeutic uses of proteasome inhibitors across various diseases, including cancer and autoimmune conditions, but does not present new clinical data.
30 citations
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July 2019 in “PloS one” This study found that T-regulatory cells, specifically the FOXP3 CD39 subset, were significantly reduced in both circulation and hair follicles of alopecia areata patients compared to healthy subjects, suggesting potential therapeutic targets.
1 citations
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February 2025 in “South Asian Research Journal of Pharmaceutical Sciences” This study used in-silico molecular docking to evaluate the antidiabetic potential of Eclipta alba leaf flavonoids, finding that compounds like apigenin, syringic acid, and vanillic acid effectively bind to the target protein aldose reductase, suggesting a promising inhibitory action.
30 citations
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October 2021 in “Scientific Reports” This study found that human scalp hair follicles can internally operate a Cori cycle, synthesize glycogen in the presence of lactate, and modulate growth through glycogen phosphorylase activity.
15 citations
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February 2014 in “Journal of Investigative Dermatology” NF-κB activity is crucial for keeping hair in the growth phase.
8 citations
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September 2016 in “Reviews in Endocrine and Metabolic Disorders” Skin health and diseases are closely linked to metabolic processes.
1 citations
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May 2015 in “Experimental Dermatology” This study found that constitutive activation of Stat3 in transgenic mice led to impaired hair growth and structural disorganization due to aberrant regulation of hair follicle and cytoskeletal genes.
March 2026 in “Virulence” This narrative review suggests that intermediate filaments like vimentin and keratin play a significant role in various stages of viral infection, presenting potential antiviral intervention targets.