1 citations
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June 2021 in “Biomolecules & Therapeutics” In this study, researchers found that activating the delta opioid receptor with a specific agonist significantly promoted hair growth in mice, suggesting potential for developing new hair-loss treatments.
July 2025 in “Journal of Investigative Dermatology” Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.
November 2022 in “Journal of Investigative Dermatology” This study found that marine-derived collagen peptides slightly promoted hair matrix proliferation and prolonged hair growth phase in human hair follicles ex vivo, suggesting potential benefits for hair loss treatment.
This study explored the molecular mechanisms by which Polygonum multiflorum may treat androgenic alopecia, suggesting it influences cell apoptosis and inflammation through specific pathways, with potential application value pending further testing.
1 citations
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May 2015 in “Experimental Dermatology” This study found that constitutive activation of Stat3 in transgenic mice led to impaired hair growth and structural disorganization due to aberrant regulation of hair follicle and cytoskeletal genes.
December 2023 in “Journal of Cosmetic Dermatology” In this study, 32 healthy adults with hair fall complaints applied a hair serum daily for 60 days, resulting in statistically significant improvements in hair growth rate, thickness, and density, without any reported adverse events.
April 2012 in “Cancer Research” This study found that Stat3 influences the differentiation and migration of keratinocytes, potentially impacting epithelial carcinogenesis, by examining Stat3 activation or deletion effects in mouse models.
July 2024 in “Journal of Investigative Dermatology” The Fas/FasL pathway may play a role in alopecia areata.
414 citations
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August 2005 in “Nature” In this study, researchers discovered that activating TERT in mouse skin epithelium triggers dormant hair follicle stem cells, leading to rapid hair growth, through a pathway independent of telomere extension.
319 citations
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November 2005 in “Proceedings of the National Academy of Sciences” This study suggests that hair follicle stem cells from transgenic mice can improve nerve regeneration and function, highlighting their potential as an autologous source for regenerative medicine.
9 citations
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March 1993 in “Biochemical Pharmacology” This study suggests that rat skin may synthesize minoxidil sulphate independently, implying the skin could contribute to minoxidil's hair growth promotion without help from the liver or other organs.
7 citations
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December 2010 in “대한의생명과학회지” In this study using C57BL/6N mice, the researchers found that skin thickness, mast cell counts, and immunoreactive density of certain cytokines increased at various stages of hair follicle growth following depilation.
1 citations
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August 2021 in “Frontiers in Genetics” This study suggests that melatonin may enhance wool growth in cashmere goats by activating sulfur metabolism genes and high-sulfur protein genes, which are crucial for providing sulfur-containing amino acids needed for wool quality.
July 2026 in “Journal of Investigative Dermatology” Baricitinib effectively stops hair loss and promotes regrowth in acute alopecia areata.
November 2024 in “Journal of Drugs in Dermatology” This article highlights the need for a comprehensive review of injectable minoxidil for hair loss, as existing treatments primarily focus on topical and oral forms of the medication.
April 2024 in “Scientific reports (Nature Publishing Group)” In this study, a combined rosemary and neem extract outperformed ketoconazole and minoxidil in treating dandruff, scalp disorders, and promoting hair growth, demonstrating potent antifungal and anti-inflammatory properties in lab settings.
October 2023 in “International Journal of Pharmaceutics” This study found that ethosome-loaded minoxidil and tocopherol acetate improved hair regeneration and regulated the microenvironment around hair follicles better than commercial minoxidil in androgenic alopecia model mice, showing promise as a treatment strategy.
29 citations
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January 2017 in “Journal of Investigative Dermatology” This study found that increased MSI2 expression in hair follicle stem cells can delay hair growth by maintaining stem cell quiescence and repressing Hedgehog signaling.
14 citations
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March 2016 in “Mechanisms of Development” This study found that BNC2 is critical for hair follicle regeneration and other developmental processes, as Bnc2−/− mice exhibit incomplete hair follicle development and developmental defects, and BNC1 cannot substitute for BNC2.
15 citations
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February 2014 in “Journal of Investigative Dermatology” NF-κB activity is crucial for keeping hair in the growth phase.
1 citations
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April 2022 in “Regenerative Therapy” This study suggests that the GDNF signaling pathway may enhance skin regeneration, as observed in axolotls and Spiny mice, indicating potential for similar processes in humans.
February 2026 in “BMC Genomics” This study found that MEG3-miRNAs are key regulators of the age-dependent crimped wool trait in Tan sheep, likely influencing primary follicle development and degeneration through immune-inflammatory pathways.
May 2024 in “Clinical Cosmetic and Investigational Dermatology” In this study, researchers reviewed the roles of autophagy and mitophagy in hair follicle cycles, exploring their potential links to hair loss and investigating how manipulating these pathways might offer new therapeutic strategies.
25 citations
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June 1998 in “Journal of Investigative Dermatology” Murine cytomegalovirus does not cause alopecia areata in these mice.
5 citations
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January 2020 in “Journal of Dermatology and Dermatologic Surgery” This review discusses the potential dermatological benefits of caffeine for hair growth, rosacea, and skin cancer, but notes significant limitations in available research.
4 citations
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May 2018 in “International Journal of Molecular Sciences” This review discusses genetically-engineered mouse models for studying melanocytes and reports no new experimental findings; it emphasizes their potential to address unanswered questions in melanoma biology.
1 citations
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December 2019 This study found that bimatoprost eye drops significantly increased eyelash length, thickness, pigmentation, and the number of eyelashes per follicle in rabbits within one month.
January 2025 in “British Journal of Dermatology” This study proposes that the ability of humans to grow long scalp hair is linked to the evolutionary adjustment of molecular checkpoints that regulate the hair growth cycle, potentially influenced by its roles in communicating age, maturity, and social signals.
September 2023 in “Cureus” This study reviewed early research on topical finasteride for androgenetic alopecia, finding it appears safe and promising, though further investigation is needed to determine optimal dosing, frequency, and potential applications for other types of alopecia.
January 2014 in “American Journal of Medicine and Medical Sciences” This article discusses the mechanisms of androgenetic alopecia and explores possible explanations for minoxidil's effect on hair growth but reports no new results.