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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

Polymeric nanoparticles show promise for treating skin diseases.

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

New effective scar treatments are urgently needed due to the current options' limited success.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Antiandrogens are somewhat effective in reducing excessive hair growth in women.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.