Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that antiandrogens may slightly reduce hirsutism severity compared to placebo, but evidence is weak and their relative efficacy remains uncertain.

This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.

This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

This study found that anagen-phase hair follicles in mice are particularly sensitive to damage by ruby laser pulses, resulting in alopecia without scarring, suggesting enhanced laser hair removal strategies.

In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.

This study developed and validated a computational model to optimize skin precooling methods for minimizing thermal damage during laser procedures.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.

This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

This review discusses pharmacologic treatment options for muscle-related pain conditions and notes that there is strong evidence for the efficacy of tricyclic antidepressants and muscle relaxants in specific myofascial pain syndromes, but not universally.

In this study, decellularized human amniotic membrane was found to promote wound healing and reduce scar formation in rats with full-thickness skin defects, compared to traditional clinical treatments.

This review discusses various rare syndromes associated with ichthyosis and emphasizes the importance of understanding their molecular genetics and mechanisms for developing effective treatments and genetic counseling, but it reports no new clinical findings.

This review discusses post-SSRI sexual dysfunction and post-finasteride syndrome, highlighting unknowns about their true incidence and underlying causes, and reports no new clinical results.

In this study, synthetic vitamin D3 analogs stimulated hair growth and formation of normal hair follicles in nude mice, unlike the natural form 1,25 dihydroxyvitamin D3.

This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.

This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.

This review discusses how the brain can influence skin biology, suggesting a link between psychological factors and skin health, but it reports no new scientific findings.

In this study, adrenalectomy in rats on a diet lacking certain vitamin B components reversed fur graying and enhanced hair growth.

This study developed a theoretical model that suggests finasteride may completely inhibit 5AR type 2, but not sufficiently suppress type 1, leading to only partial reduction of dihydrotestosterone at clinical doses.

This study found that the PLC2 gene plays a critical role in auxin-mediated root development in Arabidopsis, influencing root growth and PIN2 distribution.

This study identified a weak interaction between minoxidil and ß-cyclodextrin in solution, forming an inclusion complex with a 1:1 molar ratio.

Platelet-Rich Plasma (PRP) treatment may increase hair growth for genetic hair loss, but more research is needed to confirm this.

This study identified the placenta at the base of the ovary as the origin of poplar seed hair development and detailed transcriptome dynamics during the growth process.

This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.

This source reviews Japan's extensive 2014 reforms and investments in regenerative medicine, exploring the government's initiatives to accelerate stem cell research while maintaining safety and efficacy.

This study provided the first proteome dataset for alopecia areata, revealing novel pathways in the disease mechanisms that may lead to new therapeutic targets.

This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.