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The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Finasteride effectively treats male hair loss, improving growth and density.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Finasteride exposure harms tadpole reproduction and hormone balance.

Finasteride reduces movement issues in Parkinson's disease rats.

Starting 5-alpha reductase inhibitors does not significantly increase the risk of rhabdomyolysis in older men, but is linked to a higher risk of muscle conditions.

5-alpha reductase inhibitors might worsen lung recovery in COVID-19 patients, suggesting a pause in their use.

5-alpha reductase inhibitors may reduce bladder cancer recurrence and improve survival.

Oral finasteride and dutasteride may negatively affect erectile function in rats.

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.

Black pepper leaf extract contains compounds that can block testosterone effects and promote hair growth.

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

A plant extract was found to effectively block an enzyme related to male hormone-related diseases.

Bitter melon extract may help prevent hair loss and can be used in cosmetic products.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

The conclusion is that doctors should be careful when prescribing 5α-reductase inhibitors due to possible serious side effects, and they should discuss these risks with patients.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.