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Additional File 4 of Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Additional File 4 of Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

January 2022 in “Figshare”

Melatonin affects when and how certain genes work during the growth of goat hair follicles.

Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

September 2020 in “Current Enzyme Inhibition”

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

research Dipeptidyl-Peptidase 4 (DPP4)-Positive Fibroblasts Are Responsible for Secretion of Pro-Fibrotic Matrix Proteins in Human Skin

April 2019 in “Journal of Investigative Dermatology”

DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.

research Peer Review of Secreted Frizzled-Related Protein 4 Inhibiting Hair Follicle Regeneration

January 2019

sFRP4 partially inhibits hair regeneration, but the study needs clearer data analysis and better explanation of the process.

research Peer Review of Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles

January 2019

A protein called sFRP4 can partly inhibit hair growth.

Possible Association Between Androgenic Alopecia and Risk of Prostate Cancer and Testicular Germ Cell Tumor: A Systematic Review and Meta-Analysis

research Possible Association Between Androgenic Alopecia and Risk of Prostate Cancer and Testicular Germ Cell Tumor: A Systematic Review and Meta-Analysis

January 2018 in “Figshare”

There might be a link between male pattern baldness and a higher risk of prostate cancer and testicular cancer.

research Crystal Structure and Synthesis of 17α-Acetoxy-Pregn-4,6-Diene-3,20-Dione

June 2010 in “Journal of Chemical Crystallography”

The compound was successfully made and shows potential for treating prostate cancer.

research Study on the Expression Patterns of Thymosin β4 and Vascular Endothelial Cell Growth Factor (VEGF) in Normal Human Tissues Using Tissue Microarray

December 2009 in “생명과학회지”

Thymosin β4 and VEGF are important for organ function and may help with blood vessel formation.

research Crystal Structure and Synthesis of 3β-Benzoyloxy-4-pregnen-16α,17α-epoxy-6,20-dione

January 2004 in “Analytical Sciences: X-ray Structure Analysis Online”

The document explains how to make a compound called 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione and describes its crystal structure.

research Crystal Structure and Synthesis of 17α-Acetoxy-4-Bromopregn-4-Ene-3,20-Dione

August 2002 in “Analytical Sciences”

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

research Serum Fatty Acid Binding Protein 4 in Patients with Androgenetic Alopecia

August 2020 in “Benha Journal of Applied Sciences”

Higher FABP4 levels may help diagnose androgenetic alopecia early.

research Assessment of Retinol-Binding Protein 4 in Patients with Alopecia Areata and Androgenetic Alopecia

September 2016 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Higher RBP4 levels found in people with two types of hair loss.

research Symposium 6-4: Recent Progress in the Treatment of Male Pattern Hair Loss: Lasers and Devices

January 2014 in “프로그램북(구 초록집)”

Laser and light treatments show promise for hair growth but need more research.

research The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase

64 citations, June 1995 in “Steroids”

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations, October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III) Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-One, an Androgen Receptor Antagonist

research Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III) Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-One, an Androgen Receptor Antagonist

14 citations, February 1994 in “Tetrahedron Letters”

Adding cerium(III) chloride to Grignard reagents improves the making of compounds that could treat prostate issues and hair loss.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

12 citations, April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

7 citations, August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research Biotransformation of Tirilazad in Humans: Effect of Finasteride on Tirilazad Clearance and Reduced Metabolite Formation

3 citations, November 1998 in “PubMed”

research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-Methylpregna-4,6-Diene-3,20-Dione

2 citations, October 2001 in “Analytical Sciences”

A new compound that could treat various androgen-related conditions was created and analyzed.

research Crystal Structure and Synthesis of 17α-Acetoxy-6,7-Epoxypregn-4-ene-3,20-dione

1 citations, January 2009 in “X-ray Structure Analysis Online”

A new compound was made that might help treat diseases related to male hormones.

research Multiple Endocrine Defects in Adult-Onset Sprouty1/2/4 Triple Knockout Mice

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

Panhypopituitarism Induced by CTLA-4 and PD-1/PD-L1 Inhibitor Immunotherapy

research 17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity

December 1998 in “Acta Crystallographica Section C-crystal Structure Communications”

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

research Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity

47 citations, June 2012 in “Genes & Development”

A mother's western diet can make her milk toxic, causing inflammation and hair loss in babies.

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