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Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III) Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-One, an Androgen Receptor Antagonist

research Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III) Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-One, an Androgen Receptor Antagonist

14 citations, February 1994 in “Tetrahedron Letters”

Adding cerium(III) chloride to Grignard reagents improves the making of compounds that could treat prostate issues and hair loss.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

12 citations, April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

7 citations, August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research Biotransformation of Tirilazad in Humans: Effect of Finasteride on Tirilazad Clearance and Reduced Metabolite Formation

3 citations, November 1998 in “PubMed”

research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-Methylpregna-4,6-Diene-3,20-Dione

2 citations, October 2001 in “Analytical Sciences”

A new compound that could treat various androgen-related conditions was created and analyzed.

research Crystal Structure and Synthesis of 17α-Acetoxy-6,7-Epoxypregn-4-ene-3,20-dione

1 citations, January 2009 in “X-ray Structure Analysis Online”

A new compound was made that might help treat diseases related to male hormones.

research Multiple Endocrine Defects in Adult-Onset Sprouty1/2/4 Triple Knockout Mice

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

research Panhypopituitarism Induced by CTLA-4 and PD-1/PD-L1 Inhibitor Immunotherapy

November 2022 in “Journal of the Endocrine Society”

Immunotherapy for cancer caused a patient to develop a condition affecting hormone production, requiring ongoing hormone replacement therapy.

research Fertility and Sterility Volume 101 Number 4, April 2014

March 2014 in “Fertility and Sterility”

The April 2014 issue of "Fertility and Sterility" discussed various reproductive health topics, including hormone therapy benefits, sperm and genetic factors in male infertility, and the link between PCOS and diabetes.

research 10th Annual Meeting of the Italian Society for Hair Restoration, Modena, Italy, June 2-4, 2005

July 2005 in “Hair transplant forum international”

research Crystal Structure of 17-Beta-Benzoyloxy-16-Beta-Methylpregna-4,6-Diene-3,20-Dione

February 1999 in “Analytical Sciences”

A new antiandrogen compound was made and its detailed three-dimensional shape was described.

research 17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity

December 1998 in “Acta Crystallographica Section C-crystal Structure Communications”

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

research Maternal Western Diet Causes Inflammatory Milk and TLR2/4-Dependent Neonatal Toxicity

47 citations, June 2012 in “Genes & Development”

A mother's western diet can make her milk toxic, causing inflammation and hair loss in babies.

research Cutaneous Crohn's Disease Treated with Infliximab and 4 Years of Follow-Up

9 citations, June 2013 in “Australasian Journal of Dermatology”

Infliximab improved skin and bowel symptoms in Crohn's disease but caused side effects and the disease returned after stopping treatment.

research A Combination of Pyridine-2, 4-Dicarboxylic Acid Diethyl Ester and Resveratrol Stabilizes Hypoxia-Inducible Factor 1-Alpha and Improves Hair Density in Female Volunteers

8 citations, January 2020 in “International Journal of Cosmetic Science”

The combination of specific chemicals improves hair density in women.

research Trichilemmal Cysts With Divergent Ductal Differentiation: A Series of 4 Cases

2 citations, November 2020 in “The American journal of dermatopathology/American journal of dermatopathology”

Sweat duct differentiation in trichilemmal cysts is very rare and can be successfully removed with surgery.

research Urinary Retention in Patients with BPH Treated with Finasteride or Placebo Over 4 Years

109 citations, April 2000 in “European Urology”

Finasteride lowers risk of urinary issues and surgery by over 50% in 4 years.

research Alisertib Is Active as Single Agent in Recurrent Atypical Teratoid Rhabdoid Tumors in Four Children

65 citations, February 2015 in “Neuro-Oncology”

Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.

Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

research Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

10 citations, August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research Synthesis, Anticancer, and Molecular Docking Studies of 2-(4-Chlorophenyl)-5-Aryl-1,3,4-Oxadiazole Analogues

8 citations, January 2013 in “Medicinal chemistry”

The compound 4c showed strong potential as an anticancer agent.

research Small Cell Lung Cancer: Results of a Phase II Study of 1,2,4-Triglycidylurazol

6 citations, May 1986 in “Cancer Chemotherapy and Pharmacology”

The drug TGU was ineffective against small cell lung cancer and caused significant bone marrow suppression.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

5 citations, February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Essential Fatty Acid Deficiency in a Patient with Vascular Ehlers-Danlos Syndrome

1 citations, June 2019 in “Current developments in nutrition”

A patient with Ehlers-Danlos Syndrome improved after treatment for fat malabsorption and essential fatty acid deficiency.

Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

research Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

December 2023 in “Journal of Medicinal Chemistry”

A new topical treatment for hair loss shows strong hair growth effects with low toxicity.

research Outcomes of Down-Titration in Patients with Severe Scalp Alopecia Areata Treated with Baricitinib 4 Mg: Week 104 Data from BRAVE-AA2

September 2023 in “Journal of The American Academy of Dermatology”

Reducing the dose of Baricitinib to 2mg led to a loss of hair regrowth benefits in nearly half of the patients by Week-104.

research Loss of UBE2N in Keratinocytes Leads to Skin Inflammation and Immune Infiltration Through IRAK1/4-Mediated Processes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.

research Book Review: Integrated Procedures in Facial Cosmetic Surgery

January 2022 in “Maxillofacial Plastic and Reconstructive Surgery”

The book is a detailed guide on facial cosmetic surgery techniques and advancements, useful for both trainees and specialists.

Ultrasound-Assisted Facile Synthesis and Anticancer Evaluation of Novel N-(2-Substituted Phenyl-4-Oxathiazolidine-3-Carbonothioyl) Benzamide

research Ultrasound-Assisted Facile Synthesis and Anticancer Evaluation of Novel N-(2-Substituted Phenyl-4-Oxathiazolidine-3-Carbonothioyl) Benzamide

November 2018

Researchers made new compounds that could potentially be developed into anticancer drugs.

research Clinical Improvements in Erectile Function and Mood in Hypogonadal Men Treated with 4.5% Nasal Testosterone Gel (Natesto)

February 2018 in “The Journal of Sexual Medicine”

Natesto nasal gel improves erectile function and mood in men with low testosterone within 30 days.

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