7 citations,
July 2019 in “International Journal of Molecular Sciences” PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.
7 citations,
November 2014 in “Histochemistry and Cell Biology” The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
6 citations,
February 2014 in “International Journal of Radiation Biology” Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.
2 citations,
July 2009 in “Clinical and Experimental Dermatology” A man had rare skin tumors with bone formation and cholesterol deposits.
1 citations,
May 2021 in “Magnetic Resonance in Medical Sciences” MRI helps evaluate androgenetic alopecia severity.
1 citations,
May 2016 in “Pharmaceutical Biology” Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.
1066 citations,
March 2010 in “Nature Reviews Molecular Cell Biology” MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.
510 citations,
December 2006 in “Endocrinology” The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.
243 citations,
September 2016 in “Dermatology and Therapy” Dermoscopy is a useful tool for identifying features of skin conditions, but more research is needed to define its role in dermatology.
184 citations,
December 2018 in “Nature Communications” Researchers created human hair follicles using a new method that could help treat hair loss.
153 citations,
November 2004 in “Current Medicinal Chemistry” The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.
150 citations,
January 2018 in “Burns & Trauma” Bioprinting could improve wound healing but needs more development to match real skin.
129 citations,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
128 citations,
August 2015 in “Cell Stem Cell” Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
92 citations,
December 2012 in “Current opinion in genetics & development” Turing patterns are now recognized as important in developmental biology.
88 citations,
August 2008 in “Development” BMP2 and BMP7 have opposite roles in feather formation.
86 citations,
June 2017 in “Stem cell investigation” Stem cells from hair follicles can safely treat hair loss.
83 citations,
October 2008 in “Current Opinion in Chemical Biology” The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.
82 citations,
July 2009 in “Development” EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.
70 citations,
February 2015 in “Expert Opinion on Drug Discovery” Topical drugs and near-infrared light therapy show potential for treating alopecia.
58 citations,
February 2016 in “Scientific reports” Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.
55 citations,
October 2014 in “Development” Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.
53 citations,
October 2014 in “Free radical biology & medicine” Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.
51 citations,
August 2019 in “Biomaterials” Researchers developed a method to grow hair follicles using special beads that could help with hair loss treatment.
47 citations,
January 2019 in “Nature communications” Polyamines help fix DNA damage accurately in cells.
33 citations,
August 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
32 citations,
December 2017 in “International Journal of Molecular Sciences” Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.
31 citations,
June 2017 in “Regeneration” BMP2 needs periosteal tissue to help regenerate mouse middle finger bones within a specific time.
31 citations,
November 2016 in “Cell Reports” Touch sensitivity in mouse skin decreases during hair growth due to changes in touch receptors.
30 citations,
May 2021 in “The Journal of Sexual Medicine” Testosterone therapy can help postmenopausal women with low sexual desire if monitored carefully.