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GlossaryPPAR Agonists

activate nuclear receptors to regulate metabolism and inflammation

PPAR Agonists, or Peroxisome Proliferator-Activated Receptor Agonists, are compounds that activate PPARs, which are nuclear receptor proteins that regulate gene expression. These receptors play a crucial role in metabolism, inflammation, and cell differentiation, making PPAR agonists valuable in treating conditions like diabetes, obesity, and certain types of hair loss, such as alopecia.

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New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice

research New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today's Pre-Clinical Data into Tomorrow's Daily Clinical Practice

16 citations , July 2012 in “Current pharmaceutical biotechnology”

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

research The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia

15 citations , January 2015 in “Skin Pharmacology and Physiology”

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

research Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin

9 citations , August 2021 in “International journal of molecular sciences”

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

research How to Diagnose a Lipodystrophy Syndrome

53 citations , June 2012 in “Annales d'Endocrinologie”

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

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community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 9 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 9 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 8 months ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 414 upvotes 5 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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