research The effect of St. John’s wort treatment on finasteride pharmacokinetics and identification of new phase I and phase II metabolites in humans
St. John’s wort changes how finasteride works in the body, possibly affecting its effectiveness.
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research High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile
This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.
research Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing
This study investigated the metabolic pathways of epristeride, a new Type II 5α‐reductase inhibitor, using in vitro models and found that its metabolites show significant interactions with key proteins, suggesting implications for its role in doping control.
research Metabolomics reveals metabolites associated with hair follicle cycle in cashmere goats
In this study, researchers observed that metabolite expression patterns, including sugars, lipids, amino acids, and nucleotides, affect hair follicle growth in cashmere goats, with feeding practices potentially influencing these cycles via hormone and vitamin levels.
research Lysocellin, a metabolite of the novel drug ‘alopestatin’, induces G1 arrest and prevents cytotoxicity induced by etoposide
In this study, lysocellin induced G1 phase arrest in human osteosarcoma cells, but diminished the cytotoxic efficacy of etoposide, while its derivative alopestatin may reduce etoposide-induced alopecia in a rat model.
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5 / 1000+ resultscommunity Pp405 phase 2a clinical results
PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.
community Clascoterone 12 months phase 3 result out
Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.
community What the Breezula Phase III results mean & realistic timeline
Breezula offers modest hair growth similar to finasteride and is expected to be available by late 2026. It is a safe alternative without hormonal side effects and works well with minoxidil.
community Breezula 6 Month Topline Phase III Results Released
Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.
community Waiting to start treatment until Kintor KX-826 Phase 2 data is published?
People are waiting for KX-826 (Pyrilutamide) Phase 2 data to decide on hair loss treatments, with some considering finasteride or minoxidil in the meantime. Pyrilutamide is seen as a potentially stronger and safer alternative to finasteride, but concerns about side effects and availability remain.
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5 / 801 results- What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
- How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.
- How long does Scalp Micropigmentation last, and does it need touch-ups over time? Scalp micropigmentation lasts 2 to 8 years and requires touch-ups every 1 to 5 years.
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learn Melatonin
hormone commonly taken for sleep aid has some topical benefits for hair
learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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