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Glossary Perifollicular Infiltrate

accumulation of immune cells around hair follicles

Perifollicular infiltrate refers to the accumulation of immune cells around hair follicles. This can be a sign of inflammation or an immune response, often seen in conditions like alopecia areata, where the body's immune system mistakenly attacks hair follicles, leading to hair loss.

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Research

5 / 1000+ results

research A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin

6 citations , June 2024 in “Biofabrication”

This study used digital-light-processing bioprinting to create a 3D skin-on-a-chip model with a miniaturized vascular network to closely study immune cell interactions similar to real human skin, demonstrating the potential to analyze immune-T cell trafficking influenced by skin signals.

research Direct T-cell effects of minoxidii

7 citations , October 1988 in “Clinics in Dermatology”

Minoxidil may help hair regrowth in alopecia areata by affecting T-cells.

research Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article

1 citations , June 2022 in “The Egyptian Journal of Hospital Medicine”

This review discusses the epidemiology, clinical characteristics, pathogenesis, and genetic factors of alopecia areata, while stressing the need for targeted and effective treatments, but reports no new clinical results.

research Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics

August 2024 in “International Journal of Molecular Sciences”

The study investigated immune cell patterns around the hair follicle infundibulum in androgenetic alopecia, revealing significant differences in immune signatures between patients with AGA and control donors, specifically noting an enrichment of CD4 cells in the patient group.

Histopathological Investigation of Clinically Non-Affected Perilesional Scalp in Alopecias Detected Unexpected Spread of Disease Activities

research Histopathological investigation of clinically non‐affected perilesional scalp in alopecias detected unexpected spread of disease activities

9 citations , August 2014 in “The Journal of Dermatology”

This study found that clinically non-affected perilesional scalp in Japanese alopecia patients often showed microscopic abnormalities, which may help in assessing the spread of disease activities.

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Community Join

5 / 34 results

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

11 upvotes 2 years ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

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