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Did you mean Peptidylarginine Deiminase?

GlossaryPeptidylarginine Deiminase

enzyme converting arginine in proteins to citrulline

Peptidylarginine Deiminase (PAD) is an enzyme that converts arginine residues in proteins into citrulline through a process called deimination or citrullination. This modification can affect protein function and is involved in various physiological processes, including the regulation of gene expression and the formation of hair. Dysregulation of PAD activity has been linked to autoimmune diseases and conditions like alopecia.

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research Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin

124 citations , November 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

research Immunocytochemical Localization of Peptidylarginine Deiminase Type III, Trichohyalin, and Deiminated Trichohyalin in Infant Rat Dorsal Skin Hair Follicle

2 citations , January 2001 in “Biomedical Research”

Trichohyalin and peptidylarginine deiminase type III are found together in rat hair follicles, with trichohyalin being modified after expression.

research Isolation and Molecular Cloning of Epidermal and Hair Follicle-Specific Peptidylarginine Deiminase Type III from Rat

42 citations , May 1997 in “The Journal of Biochemistry”

PAD type III enzyme is specific to rat skin and hair follicles.

research Morphogenesis and Hair Cycle-Dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III, and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles

January 2001 in “Biomedical Research”

THH and PAD type III appear together early in hair growth, but deiminated THH appears later, suggesting another factor is involved.

research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in Anagen Hair Follicles and Other Human Skin Appendages

71 citations , June 2005 in “Journal of Investigative Dermatology”

PAD enzymes play a key role in hair growth and structure.

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