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research Hormonal Treatment of Transgender Women with Oral Estradiol

37 citations , May 2018 in “Transgender health”

This study found that oral estradiol was generally effective in achieving target 17-β estradiol levels in transgender women, but often failed to suppress testosterone adequately, with variability in individual responses.

research REAL WORLD STUDY ON ORAL ESTRADIOL TREATMENT IN TRANSGENDER WOMEN

October 2022 in “Journal of the ASEAN Federation of Endocrine Societies”

This study found that GnRH-a treatment or orchiectomy, which required significantly lower doses of oral estradiol valerate, were more effective than anti-androgens like spironolactone and finasteride in achieving target hormone levels in transgender females in India.

research An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism

18 citations , March 2010 in “Gynecologic and obstetric investigation”

This study found that both combined therapy with goserelin and oral contraceptives, and oral contraceptives alone, significantly reduced hair diameter in severe hirsutism without a significant difference between treatments.

research Noncontraceptive benefits of the estradiol valerate/dienogest combined oral contraceptive: a review of the literature

16 citations , August 2014 in “International Journal of Women's Health”

The estradiol valerate/dienogest oral contraceptive helps with heavy periods, may improve acne and symptoms in PCOS, and doesn't affect sexual function.

research Reduced serum vitamin B12 levels during oral cyproterone-acetate and ethinyl-oestradiol therapy in women with diffuse androgen-dependent alopecia

20 citations , July 1990 in “Clinical and experimental dermatology”

In this study, women treated for androgen-dependent alopecia with CPA EE2 therapy experienced significant decreases in serum vitamin B12, hemoglobin, and hematocrit levels after six months.

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learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

learn Ethynylestradiol

learn Ethinylestradiol

learn Overview

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Metformin

Is metformin used topically for hair loss, or only as an oral tablet? Approved metformin products are oral tablets only; there is no approved topical metformin for hair loss. Published human reports of topical use are a handful of uncontrolled, pharmacy-compounded case reports in scarring alopecia, and the most-cited clinical series actually used the oral drug.

learn Sulforaphane

Is sulforaphane used in oral supplements or topical hair treatments? Sulforaphane is primarily used in oral supplements, not topical hair treatments.

learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

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community After about 3 months of 2mg Estradiol (Sublingual) and 2.5mg Minox (Oral) daily

in Progress Pictures 160 upvotes 10 months ago

A person transitioning is using 2mg sublingual estradiol and 2.5mg oral minoxidil daily for hair regrowth, noting significant progress in three months. They plan to increase estrogen dosage and consider adding dutasteride, discussing the effects and challenges of transitioning.

community Oral minoxidil - how important is dermastamping?

10 months ago

A trans woman is using 10 mg oral minoxidil, dutasteride, and estradiol for hair regrowth and is also doing dermastamping despite the pain. Users discuss the benefits of dermastamping for serum absorption and hair follicle stimulation, with some expressing surprise at the high minoxidil dosage.

community 2.5 months on Oral Minoxidil (2.5mg) + Finasteride (1mg) - Early signs of progress? And also estrogen level change

10 upvotes 2 months ago

The user has been using 2.5mg oral minoxidil and 1mg finasteride daily for 2.5 months, noticing increased hair density and new hair growth. There is concern about elevated estradiol levels, possibly due to finasteride, but no significant side effects have been reported yet.

community How to choose between topical antiandrogen (Pyrilutamide) vs topical Alfatradiol (17α-estradiol) as an add-on treatment?

5 upvotes 10 months ago

The user is considering adding Pyrilutamide or Alfatradiol as a topical treatment for hair loss after oral Finasteride and Dutasteride became less effective. Other users suggest Pyrilutamide for its safety profile, while one user shares positive experiences with RU58841 for reducing scalp itch and improving hairline.

community Need supplemental products in addition to oral minoxidil and oral dutasteride

1 upvotes 1 year ago

The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

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