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community Finasteride sides on a microdose - what do I do next?

6 upvotes 4 years ago

User tried oral and topical finasteride for hair loss but experienced headaches and concentration issues. They ask for advice on whether to continue or try other treatments like alfatradiol, fluridil, or pyrilutamide.

community Minimal dose of topical minioxidil for microdosing finisteride 0.0025

in Research/Science 2 upvotes 2 years ago

Using a microdose of finasteride on the scalp with minoxidil as a carrier may have positive effects with minimal side effects. The user is also considering the effects of sulforaphane or broccoli sprouts on hair loss.

community Stopped Fin 90 days ago, still experiencing side effects.

21 upvotes 1 week ago

A user stopped taking finasteride 90 days ago but still experiences side effects like reduced sensitivity and erectile issues. They are considering micro-dosing topical finasteride and exploring other treatments like exercise and diet changes, while others suggest checking hormone levels and trying alternatives like RU58841 or dutasteride.

community Could you maintain, after a hair transplant with a topical such as Alfatradiol at 01%

6 upvotes 2 years ago

OP asked if Alfatradiol 0.1% can maintain hair after a transplant. Responses suggest using stronger treatments like finasteride or micro-dosing oral finasteride instead.

community Stemoxydine topical fin diy! Is it efficacious?

6 upvotes 4 years ago

Hair loss discussion includes using stemoxydine mixed with finasteride tablets as a topical treatment. One user reports positive results with healthy hair and new growth in hairline.

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Research

5 / 730 results

Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

research Topical Formulations Containing Finasteride. Part I: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.

Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique

research Topical Formulations Containing Finasteride. Part II: Determination of Finasteride Penetration into Hair Follicles using the Differential Stripping Technique

14 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.

research Nanoemulgel for Efficient Topical Delivery of Finasteride Against Androgenic Alopecia

6 citations , August 2020 in “Journal of Pharmaceutical Innovation”

This study found that a lipid nanoemulsion-based gel of finasteride for topical use improved hair growth and was effective against alopecia, with slow skin permeation and increased efficacy compared to a testosterone-treated group.

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.

research In That Issue: Proceedings From the Third Intercontinental Meeting of Hair Research Societies

May 2003 in “Journal of Investigative Dermatology”

This article reviews the progress in hair biology research, including advancements in understanding androgen action, hair follicle stem cells, and autoimmune mechanisms in alopecia, and reports no new clinical results.

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Learn

6 / 801 results

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether systemic side effects are genuinely rarer has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.
Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.
Finasteride for alopecia: the definitive guide to using it correctly. Finasteride 1 mg daily blocks DHT and, in trials, slowed hair loss in most men over 6 to 12 months, though some men do not respond and the benefit lasts only while the drug is taken. It is prescription-only and carries a pregnancy contraindication.

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Fluridil

a topical anti-androgen with less systemic involvement

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn Nanoxidil

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

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