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Did you mean Major Histocompatibility Complex?

Glossary Major Histocompatibility Complex

set of genes crucial for immune system's pathogen recognition

The Major Histocompatibility Complex (MHC) is a set of genes that play a crucial role in the immune system by helping the body recognize and respond to foreign substances. These genes produce proteins found on the surface of cells that present fragments of pathogens to immune cells, triggering an immune response.

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research Exploring the hair follicle immune privilege state in nonsegmental vitiligo

May 2025 in “Journal of the Egyptian Womenʼs Dermatologic Society”

This study found that immune privilege is preserved in hair follicles of nonsegmental vitiligo patients compared to those with alopecia areata, potentially protecting follicular melanocytes from autoimmune attacks.

research Effects of cyclosporine A on clinical and histologic abnormalities in dogs with sebaceous adenitis

34 citations , January 2005 in “Journal of the American Veterinary Medical Association”

This study found that cyclosporine A treatment at 5 mg/kg/day may reduce inflammation and promote gland regeneration in dogs with sebaceous adenitis, though symptoms returned when treatment stopped.

research 516 Possible role of ILC1 in the pathogenesis of alopecia areata (AA)

3 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This research suggests that innate lymphoid cells type 1 (ILC1) may contribute to the development of alopecia areata, alongside CD8+ T cells, by disrupting hair follicle immune privilege and promoting features of the disease.

research Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia?

39 citations , November 2009 in “Clinical and Experimental Dermatology”

This study reports that in primary cicatricial alopecias, increased expression of certain immune markers in the hair-follicle bulge suggests a collapse of immune privilege, which may contribute to follicle destruction.

research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

47 citations , December 2011 in “Experimental Dermatology”

This study suggests that the neuropeptide CGRP may protect against, but not restore, IFNγ-induced collapse of hair follicle immune privilege in alopecia areata.

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