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Glossary Major Histocompatibility Complex

set of genes crucial for immune system's pathogen recognition

The Major Histocompatibility Complex (MHC) is a set of genes that play a crucial role in the immune system by helping the body recognize and respond to foreign substances. These genes produce proteins found on the surface of cells that present fragments of pathogens to immune cells, triggering an immune response.

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research 875 Exploring the role of microRNAs in alopecia areata

April 2017 in “Journal of Investigative Dermatology”

This study found that miR-486 and miR-451 levels were reduced in alopecia areata-affected skin, and delivering their mimics to mice mitigated symptoms by reducing inflammation and immune activity.

research Efficacy and safety of baricitinib in patients with alopecia areata: evidence to date

September 2023 in “Drugs in context”

This article discusses baricitinib, a JAK1 and JAK2 inhibitor, as an approved and promising treatment for alopecia areata but reports no new clinical results.

research 516 Possible role of ILC1 in the pathogenesis of alopecia areata (AA)

3 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This research suggests that innate lymphoid cells type 1 (ILC1) may contribute to the development of alopecia areata, alongside CD8+ T cells, by disrupting hair follicle immune privilege and promoting features of the disease.

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

44 citations , December 2005 in “Journal of Investigative Dermatology”

This study found significant associations between certain MICA variants and haplotypes with alopecia areata, suggesting MICA as a potential candidate gene linked to the disease's susceptibility and severity.

research Nail Involvement inAutoimmune Bullous Disorders

January 2011

This study found that the nail immune system is similar to the hair follicle immune system, with both showing a relative "immune privilege" that may protect against autoimmunity.

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