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Glossary M phase

stage where a cell divides into two identical cells

The M phase, also known as the Mitotic phase, is a stage in the cell cycle where a single cell divides to produce two identical daughter cells. This phase includes both mitosis (the division of the cell's nucleus) and cytokinesis (the division of the cell's cytoplasm), ensuring that each daughter cell receives an exact copy of the parent cell's genetic material.

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Research

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research 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis

18 citations , December 2016 in “European journal of pharmacology”

In this study, 12-Chloracetyl-PPD showed anti-cancer activity by inhibiting cancer cell viability and inducing apoptosis through reactive oxygen species production without harming normal cells.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion

134 citations , January 2010 in “Biomedical research”

This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.

research The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells

9 citations , June 2020 in “BMC Molecular and Cell Biology”

This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.

research Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

8 citations , February 2021 in “Biomolecules & therapeutics”

This study found that myristoleic acid promotes dermal papilla cell proliferation and anagen signaling through autophagy, cell cycle progression, and activation of the Wnt/β-catenin and ERK pathways.

research Exploring the Role of Uc-Msc-Derived Exosomes in Boosting Hhdpcs Proliferation for Hair Growth Via Akt Activation

January 2024

In this study, human umbilical cord mesenchymal stem cell-derived exosomes were found to promote the growth of human hair dermal papilla cells, partly by enhancing AKT-dependent signaling pathways, suggesting a potential role in treating hair loss.

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Community Join

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community What was your experience with dread shed? I'm hitting the two week mark and noticing it starting and I'm getting nervous

in Minoxidil 7 upvotes 3 months ago

Minoxidil can cause initial hair shedding, but it's a sign the treatment is working. Users suggest combining it with finasteride and being patient, as hair often regrows after the shedding phase.

community Do you get a shedding phase when you change from fin to dut?

in Finasteride/Dutasteride 1 upvotes 5 months ago

A user is considering switching from finasteride to dutasteride due to unsatisfactory results and is concerned about experiencing another shedding phase. Another user recently made the switch and will update on their experience.

community VDPHL01 phase-2/3 results comparison

in Research/Science 128 upvotes 4 months ago

The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.

community What time between shedding phases?

in Treatment 1 upvotes 1 year ago

The user is using Dutasteride, Minoxidil, microneedling, RU58841, and tretinoin for hair loss. They are experiencing shedding but notice new hair growth and are curious about the timing of future shedding phases.

community This is actual growth right? The shedding phase was brutal for me. minoxidil, 5mg per day, february-april

in Is this regrowth? 17 upvotes 4 months ago

The conversation discusses hair regrowth using minoxidil, with suggestions for women to use spironolactone and for men to combine minoxidil with dutasteride. Users share experiences and advice on dosage and cost-saving methods.

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Learn

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learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Scalp micropigmentation lasts 2 to 8 years and requires touch-ups every 1 to 5 years.
What if I'm unhappy with the results of scalp micropigmentation? You can request adjustments or corrections from your provider if you're unhappy.

learn Overview

learn Thymosin Beta 4

learn Stem Cell Factor

learn Marilex-M

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Alfatradiol

Alfatradiol: Is it safe to use if I’m already on finasteride or minoxidil? No published study has tested alfatradiol together with finasteride or minoxidil, so there is no direct evidence either way — no reported interaction, but also nothing that looked for one. Community members commonly combine them without reporting problems; ask a prescriber before adding a second agent aimed at the same DHT pathway.

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