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GlossaryG1 phase

cell grows and prepares for DNA replication

The G1 phase, also known as the Gap 1 phase or First gap phase, is the first stage of the cell cycle that occurs right after a cell has divided. During this phase, the cell grows in size, produces RNA, and synthesizes proteins necessary for DNA replication. This phase is crucial for ensuring that the cell is ready for the next phase, the S phase, where DNA synthesis occurs.

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research Knockout of p16INK4a Promotes Aggregative Growth of Dermal Papilla Cells

2 citations , October 2017 in “Revista Da Associacao Medica Brasileira”

Removing p16INK4a from skin cells can lead to faster and more clumped growth, which might help with hair growth.

research Suppression of Eukaryotic Initiation Factor 4E Prevents Chemotherapy-Induced Alopecia

9 citations , November 2013 in “BMC Pharmacology and Toxicology”

Suppressing eIF4E can prevent hair loss from chemotherapy.

research Hair Regeneration Effects of Lespedeza Bicolor Extract In Vivo and In Vitro

2 citations , March 2022 in “Applied sciences”

Lespedeza bicolor extract promotes hair growth and increases hair follicle cell growth, potentially making it a better treatment than minoxidil.

research Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells

16 citations , October 2019 in “Biological & Pharmaceutical Bulletin”

Houttuynia cordata extract may help hair grow by improving cell survival and increasing cell growth.

Prostaglandin E2 Prevents Radiotherapy-Induced Alopecia by Attenuating Transit Amplifying Cell Apoptosis Through Promoting G1 Arrest

research Prostaglandin E2 Prevents Radiotherapy-Induced Alopecia by Attenuating Transit Amplifying Cell Apoptosis Through Promoting G1 Arrest

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Prostaglandin E2 helps prevent hair loss from radiotherapy by protecting hair growth cells and aiding self-repair.

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

nkrata in Research 461 upvotes 9 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.