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Did you mean Lymphocyte Infiltration?

Glossary Lymphocyte Infiltration

process where white blood cells accumulate in tissue

Lymphocyte infiltration refers to the process where lymphocytes, a type of white blood cell, move into and accumulate in a specific tissue or organ. This often occurs in response to infection, inflammation, or autoimmune conditions, where the immune system targets the body's own cells. In the context of alopecia, lymphocyte infiltration can lead to hair follicle damage, contributing to hair loss.

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Research

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Alopecia Areata But Not Androgenetic Alopecia Is Characterized By A Restricted And Oligoclonal T-Cell Receptor-Repertoire Among Infiltrating Lymphocytes

research Alopecia areata but not androgenetic alopecia is characterized by a restricted and oligoclonal T-cell receptor-repertoire among infiltrating lymphocytes

19 citations , March 1997 in “Journal of Cutaneous Pathology”

This study observed that patients with alopecia areata often have a T-cell receptor repertoire in skin lesions that suggests a specific antigen-driven immune response may be important in the disease's pathogenesis.

Immunohistochemical Insight Into the Association Between the Collapse of Immune Privilege in the Sweat Gland and Syringotropic Immune Cell Infiltrates in Collagen Diseases

research 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases

September 2017 in “Journal of Investigative Dermatology”

This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.

research Towards cell-based therapy of alopecia areata: Autologous human Vδ2+ Foxp3+ γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo

January 2026 in “Journal of Investigative Dermatology”

This study found that human γδTregs promoted hair regrowth and restored hair follicle immune privilege in a model of alopecia areata, suggesting potential for cell-based therapy in autoimmune diseases.

research Immunohistochemical analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and its comparison with androgenetic alopecia

April 2020 in “International Journal of Dermatology”

This study found that peribulbar lymphocytic infiltration can effectively differentiate between alopecia areata and androgenetic alopecia using T-cell infiltration patterns in skin tissue.

research Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata

6 citations , March 2011 in “European Journal of Dermatology”

This study observed that nestin-positive, K15-negative cells in hair follicles may play a crucial role in hair follicle regeneration in patients with alopecia areata.

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