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Did you mean Lymphocyte Infiltration?

GlossaryLymphocyte Infiltration

process where white blood cells accumulate in tissue

Lymphocyte infiltration refers to the process where lymphocytes, a type of white blood cell, move into and accumulate in a specific tissue or organ. This often occurs in response to infection, inflammation, or autoimmune conditions, where the immune system targets the body's own cells. In the context of alopecia, lymphocyte infiltration can lead to hair follicle damage, contributing to hair loss.

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research Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum

22 citations, June 2013 in “Australasian Journal of Dermatology”

Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations, November 2003 in “Veterinary pathology”

Hair loss in mice starts with immune cells damaging hair roots before it becomes visible.

research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

60 citations, September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

research Transplantation Immunology: Solid Organ and Bone Marrow

139 citations, February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Transplant success has improved with better immunosuppressive drugs and donor matching.

research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

134 citations, July 2020 in “Experimental dermatology”

Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.

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community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 6 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.