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Did you mean Ligand-Gated Ion Channel?

GlossaryIonotropic Receptor (Ligand-Gated Ion Channel)

allows ions to pass through the cell membrane upon activation

An ionotropic receptor, also known as a ligand-gated ion channel, is a type of receptor that allows ions to pass through the cell membrane in response to the binding of a chemical messenger, such as a neurotransmitter. When the neurotransmitter binds to the receptor, it causes the channel to open, allowing specific ions like sodium, potassium, or calcium to flow into or out of the cell, which can trigger various cellular responses.

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research Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain

50 citations, May 2019 in “Drugs”

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

research Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences

29 citations, July 2004 in “Pharmacology, Biochemistry and Behavior”

Finasteride reduces alcohol withdrawal effects, especially in female mice.

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

137 citations, March 2006 in “Cns Drug Reviews”

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

research GABAA Receptor Modulation by Neurosteroids in Models of Temporal Lobe Epilepsies

40 citations, December 2012 in “Epilepsia”

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

research Past and Future Strategies for GPCR Deorphanization

1 citations, July 2010

Finding functions for unknown GPCRs is hard but key for making new drugs.

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community Ligand Chem cease trading Pyrilutamide

in Product 14 upvotes 1 year ago

Pyrilutamide, a possible hair loss treatment, ceasing to be traded due to patent laws; and the hope that this indicates it may be a legitimate treatment.

community Dropping RU , not responding..

in Treatment 6 upvotes 5 months ago

The user has been using RU58841 for 6 months without noticeable results and is considering dropping it while continuing oral minoxidil, daily dutasteride, and topical minoxidil. Another user suggests visiting a dermatologist to check for other conditions.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 2 weeks ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community Boys how is no one seeing positive results from pyrilutamide

in Chat 27 upvotes 1 year ago

Pyrilutimide, a treatment for hair loss; it's effectiveness compared to other treatments such as Finasteride and RU58841; and some users’ experiences with the treatment.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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